Limits...
Concurrent Chagas' disease and borderline disseminated cutaneous leishmaniasis: The role of amiodarone as an antitrypanosomatidae drug.

Paniz-Mondolfi AE, Pérez-Alvarez AM, Reyes-Jaimes O, Socorro G, Zerpa O, Slova D, Concepción JL - Ther Clin Risk Manag (2008)

Bottom Line: Unfortunately, the possibilities for treating flagellated kinetoplastid infections are still very limited and most of the available drugs exhibit severe side effects.Although the development of new drugs for Leishmania has markedly improved in the last years, the tendency is still to employ antimonial compounds.The following case report substantiates the recently discovered effect of amiodarone as a nonconventional antiparasitic drug, particularly against Leishmania, breaching a new perspective in the therapeutic management of these important infectious parasitic diseases.

View Article: PubMed Central - PubMed

Affiliation: Laboratorio de Estudio de Antígenos, Instituto de Biomedicina, "Hospital José Gregório Hernández", Instituto Venezolano de los Seguros Sociales Caracas, Venezuela.

ABSTRACT
The occurrence of mixed infections of Trypanosoma cruzi and Leishmania spp. is becoming a common feature in Central and South America due to overlapping endemic areas. Unfortunately, the possibilities for treating flagellated kinetoplastid infections are still very limited and most of the available drugs exhibit severe side effects. Although the development of new drugs for Leishmania has markedly improved in the last years, the tendency is still to employ antimonial compounds. On the other hand, treatment for Chagas' disease is only available for the acute phase with no effective therapeutical options for chronic stage disease. The following case report substantiates the recently discovered effect of amiodarone as a nonconventional antiparasitic drug, particularly against Leishmania, breaching a new perspective in the therapeutic management of these important infectious parasitic diseases.

No MeSH data available.


Related in: MedlinePlus

Satellite disseminated acneiform lesions with moderate perilesional infiltration.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2500262&req=5

fig2: Satellite disseminated acneiform lesions with moderate perilesional infiltration.

Mentions: Upon admission and initial evaluation, he was found to have a 7 × 5 × 4.5 cm ulcer with heavily infiltrated borders and multiple satellite infiltrated nodular and acneiform lesions measuring 2 cm in diameter with the largest located at only 5 cm from the primary ulcerated lesion (Figures 1 and 2). A Giemsa-stained skin smear revealed the presence of few amastigotes in the lesions (Figure 3) and delayed type hypersensitivity (DTH) skin-test was negative. Histological sections of the lesions revealed a vacuolated granuloma exhibiting large collections of vacuolated and heavily parasitized macrophages surrounded by a lympho plasmacytic infiltrate (Figure 4). Further parasite culture and typification confirmed the presence of Leishmania (Viannia) braziliensis as the etiologic agent.


Concurrent Chagas' disease and borderline disseminated cutaneous leishmaniasis: The role of amiodarone as an antitrypanosomatidae drug.

Paniz-Mondolfi AE, Pérez-Alvarez AM, Reyes-Jaimes O, Socorro G, Zerpa O, Slova D, Concepción JL - Ther Clin Risk Manag (2008)

Satellite disseminated acneiform lesions with moderate perilesional infiltration.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2500262&req=5

fig2: Satellite disseminated acneiform lesions with moderate perilesional infiltration.
Mentions: Upon admission and initial evaluation, he was found to have a 7 × 5 × 4.5 cm ulcer with heavily infiltrated borders and multiple satellite infiltrated nodular and acneiform lesions measuring 2 cm in diameter with the largest located at only 5 cm from the primary ulcerated lesion (Figures 1 and 2). A Giemsa-stained skin smear revealed the presence of few amastigotes in the lesions (Figure 3) and delayed type hypersensitivity (DTH) skin-test was negative. Histological sections of the lesions revealed a vacuolated granuloma exhibiting large collections of vacuolated and heavily parasitized macrophages surrounded by a lympho plasmacytic infiltrate (Figure 4). Further parasite culture and typification confirmed the presence of Leishmania (Viannia) braziliensis as the etiologic agent.

Bottom Line: Unfortunately, the possibilities for treating flagellated kinetoplastid infections are still very limited and most of the available drugs exhibit severe side effects.Although the development of new drugs for Leishmania has markedly improved in the last years, the tendency is still to employ antimonial compounds.The following case report substantiates the recently discovered effect of amiodarone as a nonconventional antiparasitic drug, particularly against Leishmania, breaching a new perspective in the therapeutic management of these important infectious parasitic diseases.

View Article: PubMed Central - PubMed

Affiliation: Laboratorio de Estudio de Antígenos, Instituto de Biomedicina, "Hospital José Gregório Hernández", Instituto Venezolano de los Seguros Sociales Caracas, Venezuela.

ABSTRACT
The occurrence of mixed infections of Trypanosoma cruzi and Leishmania spp. is becoming a common feature in Central and South America due to overlapping endemic areas. Unfortunately, the possibilities for treating flagellated kinetoplastid infections are still very limited and most of the available drugs exhibit severe side effects. Although the development of new drugs for Leishmania has markedly improved in the last years, the tendency is still to employ antimonial compounds. On the other hand, treatment for Chagas' disease is only available for the acute phase with no effective therapeutical options for chronic stage disease. The following case report substantiates the recently discovered effect of amiodarone as a nonconventional antiparasitic drug, particularly against Leishmania, breaching a new perspective in the therapeutic management of these important infectious parasitic diseases.

No MeSH data available.


Related in: MedlinePlus