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Performance of the OptiMAL dipstick in the diagnosis of malaria infection in pregnancy.

Tagbor H, Bruce J, Browne E, Greenwood B, Chandramohan D - Ther Clin Risk Manag (2008)

Bottom Line: The accuracy of OptiMAL((R)) dipsticks was compared with that of microscopy in the diagnosis of malaria infection in pregnancy.OptiMAL((R)) dipsticks had a sensitivity of 96.6%, specificity of 85.4%, a positive predictive value of 92.7%, a negative predictive value of 92.6%, and an area under the ROC curve of 0.91 (95% CI of 0.90-0.92).The diagnostic accuracy of the OptiMAL((R)) dipstick is high and the test may have practical use in the diagnosis of malaria infection in pregnancy in malaria endemic countries.

View Article: PubMed Central - PubMed

Affiliation: Department of Community Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology Kumasi, Ghana.

ABSTRACT
The accuracy of OptiMAL((R)) dipsticks was compared with that of microscopy in the diagnosis of malaria infection in pregnancy. During the course of a clinical trial of antimalarial drugs in pregnancy, we screened 4500 pregnant women of all parities who accessed antenatal clinic services at St. Theresa's Hospital's in Nkoranza, Ghana, between March 2003 and December 2004 with OptiMAL((R)) dipsticks and confirmed the diagnosis of malaria with microscopy. We determined the sensitivity, specificity, positive and negative predictive values, and the area under receiver operating characteristic (ROC) curve for the OptiMAL((R)) antigen test compared to microscopy for the diagnosis of malaria infection in pregnancy. OptiMAL((R)) dipsticks had a sensitivity of 96.6%, specificity of 85.4%, a positive predictive value of 92.7%, a negative predictive value of 92.6%, and an area under the ROC curve of 0.91 (95% CI of 0.90-0.92). The diagnostic accuracy of the OptiMAL((R)) dipstick is high and the test may have practical use in the diagnosis of malaria infection in pregnancy in malaria endemic countries.

No MeSH data available.


Related in: MedlinePlus

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Mentions: A total of 6370 OptiMAL® tests were performed on 4500 pregnant women, 1338 (21%) tests were positive and 5032 were negative (Figure 1). Ninety-four slides of 1281 OptiMAL® positive women assessed microscopically were negative while 44 (7.3%) of 598 slides obtained from OptiMAL® test negative women were positive on microscopy. Fifty-seven women who had a positive OptiMAL® test did not have a blood slide collected because they declined consent before further samples could be taken or the screening process completed.


Performance of the OptiMAL dipstick in the diagnosis of malaria infection in pregnancy.

Tagbor H, Bruce J, Browne E, Greenwood B, Chandramohan D - Ther Clin Risk Manag (2008)

Study profile.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2500256&req=5

fig1: Study profile.
Mentions: A total of 6370 OptiMAL® tests were performed on 4500 pregnant women, 1338 (21%) tests were positive and 5032 were negative (Figure 1). Ninety-four slides of 1281 OptiMAL® positive women assessed microscopically were negative while 44 (7.3%) of 598 slides obtained from OptiMAL® test negative women were positive on microscopy. Fifty-seven women who had a positive OptiMAL® test did not have a blood slide collected because they declined consent before further samples could be taken or the screening process completed.

Bottom Line: The accuracy of OptiMAL((R)) dipsticks was compared with that of microscopy in the diagnosis of malaria infection in pregnancy.OptiMAL((R)) dipsticks had a sensitivity of 96.6%, specificity of 85.4%, a positive predictive value of 92.7%, a negative predictive value of 92.6%, and an area under the ROC curve of 0.91 (95% CI of 0.90-0.92).The diagnostic accuracy of the OptiMAL((R)) dipstick is high and the test may have practical use in the diagnosis of malaria infection in pregnancy in malaria endemic countries.

View Article: PubMed Central - PubMed

Affiliation: Department of Community Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology Kumasi, Ghana.

ABSTRACT
The accuracy of OptiMAL((R)) dipsticks was compared with that of microscopy in the diagnosis of malaria infection in pregnancy. During the course of a clinical trial of antimalarial drugs in pregnancy, we screened 4500 pregnant women of all parities who accessed antenatal clinic services at St. Theresa's Hospital's in Nkoranza, Ghana, between March 2003 and December 2004 with OptiMAL((R)) dipsticks and confirmed the diagnosis of malaria with microscopy. We determined the sensitivity, specificity, positive and negative predictive values, and the area under receiver operating characteristic (ROC) curve for the OptiMAL((R)) antigen test compared to microscopy for the diagnosis of malaria infection in pregnancy. OptiMAL((R)) dipsticks had a sensitivity of 96.6%, specificity of 85.4%, a positive predictive value of 92.7%, a negative predictive value of 92.6%, and an area under the ROC curve of 0.91 (95% CI of 0.90-0.92). The diagnostic accuracy of the OptiMAL((R)) dipstick is high and the test may have practical use in the diagnosis of malaria infection in pregnancy in malaria endemic countries.

No MeSH data available.


Related in: MedlinePlus