Limits...
National trends and disparities in the incidence of hepatocellular carcinoma, 1998-2003.

Ahmed F, Perz JF, Kwong S, Jamison PM, Friedman C, Bell BP - Prev Chronic Dis (2008)

Bottom Line: The annual percentage of change was highest for people aged 45-59 years (9.0%, P < .05).The annual percentage of change for Asians/Pacific Islanders was statistically unchanged.Efforts to collect representative etiologic data on new hepatocellular carcinoma cases are needed to enable better characterization of trends and to guide the planning and evaluation of prevention programs.

View Article: PubMed Central - PubMed

Affiliation: Centers for Disease Control and Prevention, 1600 Clifton Rd, MS E-52, Atlanta, GA 30333, USA. fahmed@cdc.gov

ABSTRACT

Introduction: Previous studies indicate that the incidence of hepatocellular carcinoma in the United States is increasing. These reports, however, have contained limited information on population groups other than whites and blacks.

Methods: We assessed recent incidence rates and trends for hepatocellular carcinoma by using newly available national data from cancer registries participating in the Centers for Disease Control and Prevention's National Program of Cancer Registries and the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. Data from registries in 38 states and the District of Columbia met our criteria; these data covered 83% of the U.S. population. We computed age-adjusted incidence rates and annual percentages of change from 1998 through 2003.

Results: The registries that we used reported 48,048 cases of hepatocellular carcinoma (3.4 cases per 100,000 population per year) for the study period. Whites accounted for three-fourths of cases. The incidence rate for blacks was 1.7 times higher than that for whites, and the rate for Asians/Pacific Islanders was 4 times higher than that for whites. Hispanics had 2.5 times the risk of non-Hispanics. Among Asian/Pacific Islander subgroups, rates were highest for people of Vietnamese and Korean origin. For all races/ethnicities combined, the annual percentages of change were 4.8% for males and 4.3% for females (P < .05). The annual percentage of change was highest for people aged 45-59 years (9.0%, P < .05). The annual percentage of change for Asians/Pacific Islanders was statistically unchanged.

Conclusion: We document rising incidence rates of hepatocellular carcinoma in the United States during a time when the overall incidence of cancer has stabilized. Efforts to collect representative etiologic data on new hepatocellular carcinoma cases are needed to enable better characterization of trends and to guide the planning and evaluation of prevention programs.

Show MeSH

Related in: MedlinePlus

Annual Percentage Change (APC) in Incidence of Hepatocellular Carcinoma, United States, 1998–2003.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2483571&req=5

Figure 2: Annual Percentage Change (APC) in Incidence of Hepatocellular Carcinoma, United States, 1998–2003.

Mentions: The age-adjusted incidence rate for males rose from 5.0 in 1998 to 6.2 in 2003, an increase of 24% (age-adjusted RR, 1.25; P < .05) (Table 1). For females, incidence in 2003 was 31% higher than in 1998 (age-adjusted RR, 1.27; P < .05). The APC was 4.8% (P < .05) for males and 4.3% (P < .05) for females. We found significant increasing trends for males in all racial/ethnic subgroups except Asians/Pacific Islanders; for females, only whites had a significant increasing trend (Figure 2). In the specific age groups examined, the largest increases occurred among patients aged 45–59 years at diagnosis (APC 9.0% for men and for women). Among men aged 45–59 years at diagnosis, whites, blacks, and Hispanics had significant increases each year, ranging from 9% to 10%; rates for Asian/Pacific Islander males were statistically unchanged. The pattern by race was similar for women aged 45–59 years at diagnosis, with the exception of the pattern for Hispanics (Figure 2).


National trends and disparities in the incidence of hepatocellular carcinoma, 1998-2003.

Ahmed F, Perz JF, Kwong S, Jamison PM, Friedman C, Bell BP - Prev Chronic Dis (2008)

Annual Percentage Change (APC) in Incidence of Hepatocellular Carcinoma, United States, 1998–2003.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2483571&req=5

Figure 2: Annual Percentage Change (APC) in Incidence of Hepatocellular Carcinoma, United States, 1998–2003.
Mentions: The age-adjusted incidence rate for males rose from 5.0 in 1998 to 6.2 in 2003, an increase of 24% (age-adjusted RR, 1.25; P < .05) (Table 1). For females, incidence in 2003 was 31% higher than in 1998 (age-adjusted RR, 1.27; P < .05). The APC was 4.8% (P < .05) for males and 4.3% (P < .05) for females. We found significant increasing trends for males in all racial/ethnic subgroups except Asians/Pacific Islanders; for females, only whites had a significant increasing trend (Figure 2). In the specific age groups examined, the largest increases occurred among patients aged 45–59 years at diagnosis (APC 9.0% for men and for women). Among men aged 45–59 years at diagnosis, whites, blacks, and Hispanics had significant increases each year, ranging from 9% to 10%; rates for Asian/Pacific Islander males were statistically unchanged. The pattern by race was similar for women aged 45–59 years at diagnosis, with the exception of the pattern for Hispanics (Figure 2).

Bottom Line: The annual percentage of change was highest for people aged 45-59 years (9.0%, P < .05).The annual percentage of change for Asians/Pacific Islanders was statistically unchanged.Efforts to collect representative etiologic data on new hepatocellular carcinoma cases are needed to enable better characterization of trends and to guide the planning and evaluation of prevention programs.

View Article: PubMed Central - PubMed

Affiliation: Centers for Disease Control and Prevention, 1600 Clifton Rd, MS E-52, Atlanta, GA 30333, USA. fahmed@cdc.gov

ABSTRACT

Introduction: Previous studies indicate that the incidence of hepatocellular carcinoma in the United States is increasing. These reports, however, have contained limited information on population groups other than whites and blacks.

Methods: We assessed recent incidence rates and trends for hepatocellular carcinoma by using newly available national data from cancer registries participating in the Centers for Disease Control and Prevention's National Program of Cancer Registries and the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. Data from registries in 38 states and the District of Columbia met our criteria; these data covered 83% of the U.S. population. We computed age-adjusted incidence rates and annual percentages of change from 1998 through 2003.

Results: The registries that we used reported 48,048 cases of hepatocellular carcinoma (3.4 cases per 100,000 population per year) for the study period. Whites accounted for three-fourths of cases. The incidence rate for blacks was 1.7 times higher than that for whites, and the rate for Asians/Pacific Islanders was 4 times higher than that for whites. Hispanics had 2.5 times the risk of non-Hispanics. Among Asian/Pacific Islander subgroups, rates were highest for people of Vietnamese and Korean origin. For all races/ethnicities combined, the annual percentages of change were 4.8% for males and 4.3% for females (P < .05). The annual percentage of change was highest for people aged 45-59 years (9.0%, P < .05). The annual percentage of change for Asians/Pacific Islanders was statistically unchanged.

Conclusion: We document rising incidence rates of hepatocellular carcinoma in the United States during a time when the overall incidence of cancer has stabilized. Efforts to collect representative etiologic data on new hepatocellular carcinoma cases are needed to enable better characterization of trends and to guide the planning and evaluation of prevention programs.

Show MeSH
Related in: MedlinePlus