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HELPING CELLS LOSE THEIR INHIBITIONS

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But cells sometimes need to get pushy, and a membrane protein allows them to remain mobile after making contact, Nakao et al. show... However, normal cells also have to shed this restraint during wound healing and development... Nakao et al. found a possible trigger for the behavior while studying OL-protocadherin (OL-pc), a member of the cadherin family of membrane proteins that typically fasten cells together... The team found that neurons from mice missing OL-pc couldn't extend their axons... Nakao et al. inserted the gene for OL-pc into nervous system tumor cells that normally can't make the protein... Isolated cells moseyed along, the researchers found, but they sped up in crowded cultures in which cells frequently make contact... A protein complex containing Nap1 and WAVE1 promotes migration, and Nakao et al. discovered that OL-pc delivers it to sites of cell–cell contact... Cells without OL-pc slithered slowly into the scrape, maintaining contact with each other... Cells that manufactured the protein, by contrast, rushed in haphazardly, often leaving their neighbors behind... That result suggests that instead of building contacts between cells like other cadherins do, OL-pc breaks the connections that help coordinate cell behavior... Whether OL-pc contributes to cancer cells' lack of contact inhibition remains to be seen.

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OL-protocadherin ushers the migration-stimulating protein Nap1 to cell junctions (arrowheads).
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fig1: OL-protocadherin ushers the migration-stimulating protein Nap1 to cell junctions (arrowheads).


HELPING CELLS LOSE THEIR INHIBITIONS
OL-protocadherin ushers the migration-stimulating protein Nap1 to cell junctions (arrowheads).
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC2483524&req=5

fig1: OL-protocadherin ushers the migration-stimulating protein Nap1 to cell junctions (arrowheads).

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

But cells sometimes need to get pushy, and a membrane protein allows them to remain mobile after making contact, Nakao et al. show... However, normal cells also have to shed this restraint during wound healing and development... Nakao et al. found a possible trigger for the behavior while studying OL-protocadherin (OL-pc), a member of the cadherin family of membrane proteins that typically fasten cells together... The team found that neurons from mice missing OL-pc couldn't extend their axons... Nakao et al. inserted the gene for OL-pc into nervous system tumor cells that normally can't make the protein... Isolated cells moseyed along, the researchers found, but they sped up in crowded cultures in which cells frequently make contact... A protein complex containing Nap1 and WAVE1 promotes migration, and Nakao et al. discovered that OL-pc delivers it to sites of cell–cell contact... Cells without OL-pc slithered slowly into the scrape, maintaining contact with each other... Cells that manufactured the protein, by contrast, rushed in haphazardly, often leaving their neighbors behind... That result suggests that instead of building contacts between cells like other cadherins do, OL-pc breaks the connections that help coordinate cell behavior... Whether OL-pc contributes to cancer cells' lack of contact inhibition remains to be seen.

No MeSH data available.