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A rare myoepithelioma of the sinonasal cavity: case report.

Sayed SI, Kazi RA, Jagade MV, Palav RS, Shinde VV, Pawar PV - Cases J (2008)

Bottom Line: Pure accounting for less than 1% of all salivary gland tumors.The lesion is so rare that there are no specific indications/guidelines for its treatment.Most are benign, but some can be malignant.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of ENT and Head and Neck surgery, Grants medical college and Sir JJ group of hospitals, Mumbai 400008, India. drsuhailsayed@yahoo.com.

ABSTRACT
Myoepithelioma is a rare benign neoplasm. Pure accounting for less than 1% of all salivary gland tumors. Only three cases of sinonasal myoepithelioma have been reported in the literature. Diagnosis of myoepithelioma through light microscopy is possible and immunohistochemistry is done to facilitate the diagnosis. The lesion is so rare that there are no specific indications/guidelines for its treatment. We report to you a rare case of sinonasal myoepithelioma in a 57 year old Asian female.Myoepitheliomas are rare tumours that account for only about 1% of all salivary gland tumors. Most are benign, but some can be malignant. Only three cases of sinonasal myoepithelioma have been reported in the literature so far.

No MeSH data available.


Related in: MedlinePlus

Tumour is composed of small and/or medium spindle shaped cells, differently interlaced, with eosinophilic cytoplasm, that occur in sheets or swirls and have round to oval nuclei with finely dispersed chromatin. Stroma is myxomatous. Myoepithelial cells stain strongly positive for Calponin (40×).
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Figure 3: Tumour is composed of small and/or medium spindle shaped cells, differently interlaced, with eosinophilic cytoplasm, that occur in sheets or swirls and have round to oval nuclei with finely dispersed chromatin. Stroma is myxomatous. Myoepithelial cells stain strongly positive for Calponin (40×).

Mentions: Subsequently, following a multidisciplinary meeting, the patient underwent a sublabial surgical approach for resection of the tumor. On table the sessile, encapsulated, pinkish red and firm tumor was occupying whole of the nasal cavity with the septum pushed to the left side. Histopathological examination of the specimen revealed loose clusters of plasmacytoid (hyaline) small and/or medium sized spindle shaped cells, differently interlaced, with eosinophilic cytoplasm, occurring in sheets or swirls; the nuclei were predominantly round to ovoid in shape, often eccentric, with finely dispersed chromatin and low mitotic activity. Further Immunohistochemical studies revealed positivity to Calponin (Figure 3). These results were consistent with the rare diagnosis of a sinonasal myoepithelioma. Patient had no recurrence during a follow-up period of 2 years.


A rare myoepithelioma of the sinonasal cavity: case report.

Sayed SI, Kazi RA, Jagade MV, Palav RS, Shinde VV, Pawar PV - Cases J (2008)

Tumour is composed of small and/or medium spindle shaped cells, differently interlaced, with eosinophilic cytoplasm, that occur in sheets or swirls and have round to oval nuclei with finely dispersed chromatin. Stroma is myxomatous. Myoepithelial cells stain strongly positive for Calponin (40×).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2483262&req=5

Figure 3: Tumour is composed of small and/or medium spindle shaped cells, differently interlaced, with eosinophilic cytoplasm, that occur in sheets or swirls and have round to oval nuclei with finely dispersed chromatin. Stroma is myxomatous. Myoepithelial cells stain strongly positive for Calponin (40×).
Mentions: Subsequently, following a multidisciplinary meeting, the patient underwent a sublabial surgical approach for resection of the tumor. On table the sessile, encapsulated, pinkish red and firm tumor was occupying whole of the nasal cavity with the septum pushed to the left side. Histopathological examination of the specimen revealed loose clusters of plasmacytoid (hyaline) small and/or medium sized spindle shaped cells, differently interlaced, with eosinophilic cytoplasm, occurring in sheets or swirls; the nuclei were predominantly round to ovoid in shape, often eccentric, with finely dispersed chromatin and low mitotic activity. Further Immunohistochemical studies revealed positivity to Calponin (Figure 3). These results were consistent with the rare diagnosis of a sinonasal myoepithelioma. Patient had no recurrence during a follow-up period of 2 years.

Bottom Line: Pure accounting for less than 1% of all salivary gland tumors.The lesion is so rare that there are no specific indications/guidelines for its treatment.Most are benign, but some can be malignant.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of ENT and Head and Neck surgery, Grants medical college and Sir JJ group of hospitals, Mumbai 400008, India. drsuhailsayed@yahoo.com.

ABSTRACT
Myoepithelioma is a rare benign neoplasm. Pure accounting for less than 1% of all salivary gland tumors. Only three cases of sinonasal myoepithelioma have been reported in the literature. Diagnosis of myoepithelioma through light microscopy is possible and immunohistochemistry is done to facilitate the diagnosis. The lesion is so rare that there are no specific indications/guidelines for its treatment. We report to you a rare case of sinonasal myoepithelioma in a 57 year old Asian female.Myoepitheliomas are rare tumours that account for only about 1% of all salivary gland tumors. Most are benign, but some can be malignant. Only three cases of sinonasal myoepithelioma have been reported in the literature so far.

No MeSH data available.


Related in: MedlinePlus