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Rapid progression of prostate cancer in men with a BRCA2 mutation.

Narod SA, Neuhausen S, Vichodez G, Armel S, Lynch HT, Ghadirian P, Cummings S, Olopade O, Stoppa-Lyonnet D, Couch F, Wagner T, Warner E, Foulkes WD, Saal H, Weitzel J, Tulman A, Poll A, Nam R, Sun P, Hereditary Breast Cancer Study GroupDanquah J, Domchek S, Tung N, Ainsworth P, Horsman D, Kim-Sing C, Maugard C, Eisen A, Daly M, McKinnon W, Wood M, Isaacs C, Gilchrist D, Karlan B, Nedelcu R, Meschino W, Garber J, Pasini B, Manoukian S, Bellati C - Br. J. Cancer (2008)

Bottom Line: Men with BRCA2 mutations have been found to be at increased risk of developing prostate cancer.The median survival from diagnosis was 4.0 years for men with a BRCA2 mutation vs 8.0 years for men with a BRCA1 mutation, and the difference was highly significant (P<0.01).It may be important to develop targeted chemotherapies to treat prostate cancer in men with a BRCA2 mutation.

View Article: PubMed Central - PubMed

Affiliation: Women's College Research Institute, 790 Bay Street, 7th Floor, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada. steven.narod@wchospital.ca

ABSTRACT
Men with BRCA2 mutations have been found to be at increased risk of developing prostate cancer. There is a recent report that BRCA2 carriers with prostate cancer have poorer survival than noncarrier prostate cancer patients. In this study, we compared survival of men with a BRCA2 mutation and prostate cancer with that of men with a BRCA1 mutation and prostate cancer. We obtained the age at diagnosis, age at death or current age from 182 men with prostate cancer from families with a BRCA2 mutation and from 119 men with prostate cancer from families with a BRCA1 mutation. The median survival from diagnosis was 4.0 years for men with a BRCA2 mutation vs 8.0 years for men with a BRCA1 mutation, and the difference was highly significant (P<0.01). It may be important to develop targeted chemotherapies to treat prostate cancer in men with a BRCA2 mutation.

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Related in: MedlinePlus

Probability of survival after prostate cancer in known carriers with BRCA1 and BRCA2 (all causes of death).
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fig2: Probability of survival after prostate cancer in known carriers with BRCA1 and BRCA2 (all causes of death).

Mentions: The analysis was then repeated, including only known carriers (67 BRCA2 and 37 BRCA1). The median survival time was 15 years for carriers of a BRCA1 mutation and was 5.0 years for carriers of a BRCA2 mutation (Figure 2). The 5-year overall survival was 64% for BRCA1 carriers and 42% for BRCA2 carriers. The 10-year survival was 60% for BRCA1 carriers and 26% for BRCA2 carriers. The 15-year overall survival was 50% for BRCA1 carriers and 4% for BRCA2 carriers. We estimated the hazard ratio for all-cause mortality for BRCA2 vs BRCA1 carriers, adjusted for age, over the entire follow-up period. The hazard ratio was 2.5 (95% CI 1.3–4.7; P=0.005).


Rapid progression of prostate cancer in men with a BRCA2 mutation.

Narod SA, Neuhausen S, Vichodez G, Armel S, Lynch HT, Ghadirian P, Cummings S, Olopade O, Stoppa-Lyonnet D, Couch F, Wagner T, Warner E, Foulkes WD, Saal H, Weitzel J, Tulman A, Poll A, Nam R, Sun P, Hereditary Breast Cancer Study GroupDanquah J, Domchek S, Tung N, Ainsworth P, Horsman D, Kim-Sing C, Maugard C, Eisen A, Daly M, McKinnon W, Wood M, Isaacs C, Gilchrist D, Karlan B, Nedelcu R, Meschino W, Garber J, Pasini B, Manoukian S, Bellati C - Br. J. Cancer (2008)

Probability of survival after prostate cancer in known carriers with BRCA1 and BRCA2 (all causes of death).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2480973&req=5

fig2: Probability of survival after prostate cancer in known carriers with BRCA1 and BRCA2 (all causes of death).
Mentions: The analysis was then repeated, including only known carriers (67 BRCA2 and 37 BRCA1). The median survival time was 15 years for carriers of a BRCA1 mutation and was 5.0 years for carriers of a BRCA2 mutation (Figure 2). The 5-year overall survival was 64% for BRCA1 carriers and 42% for BRCA2 carriers. The 10-year survival was 60% for BRCA1 carriers and 26% for BRCA2 carriers. The 15-year overall survival was 50% for BRCA1 carriers and 4% for BRCA2 carriers. We estimated the hazard ratio for all-cause mortality for BRCA2 vs BRCA1 carriers, adjusted for age, over the entire follow-up period. The hazard ratio was 2.5 (95% CI 1.3–4.7; P=0.005).

Bottom Line: Men with BRCA2 mutations have been found to be at increased risk of developing prostate cancer.The median survival from diagnosis was 4.0 years for men with a BRCA2 mutation vs 8.0 years for men with a BRCA1 mutation, and the difference was highly significant (P<0.01).It may be important to develop targeted chemotherapies to treat prostate cancer in men with a BRCA2 mutation.

View Article: PubMed Central - PubMed

Affiliation: Women's College Research Institute, 790 Bay Street, 7th Floor, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada. steven.narod@wchospital.ca

ABSTRACT
Men with BRCA2 mutations have been found to be at increased risk of developing prostate cancer. There is a recent report that BRCA2 carriers with prostate cancer have poorer survival than noncarrier prostate cancer patients. In this study, we compared survival of men with a BRCA2 mutation and prostate cancer with that of men with a BRCA1 mutation and prostate cancer. We obtained the age at diagnosis, age at death or current age from 182 men with prostate cancer from families with a BRCA2 mutation and from 119 men with prostate cancer from families with a BRCA1 mutation. The median survival from diagnosis was 4.0 years for men with a BRCA2 mutation vs 8.0 years for men with a BRCA1 mutation, and the difference was highly significant (P<0.01). It may be important to develop targeted chemotherapies to treat prostate cancer in men with a BRCA2 mutation.

Show MeSH
Related in: MedlinePlus