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Enhancement of Tissue Expansion by Calcium Channel Blocker: A preliminary study.

Copcu E, Sivrioglu N, Sisman N, Aktas A, Oztan Y - World J Surg Oncol (2003)

Bottom Line: Following extraction of the expanders, the flaps were elevated and less retraction was observed in the study group compared to controls.CONCLUSION: Verapamil is safe when used topically and provides less retracted flaps.It can be suggested that verapamil acts on the myofibroblasts in the capsule around tissue expanders and thus increases efficiency of the expanders.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of the Plastic and Reconstructive Surgery, Medical Faculty, Adnan Menderes University, Aydin, Turkey. copcu@lycos.com

ABSTRACT
BACKGROUND: Reconstruction of the defects after surgical resection of tumors is one of the important issues in surgical oncology. It is essential that the defect should be covered with a tissue quite similar to the original one and is best achieved by harvesting tissue from an area adjacent to the defect. Tissue expansion is one of the most frequently used reconstructive techniques. A number of studies evaluated blood circulation, capsule formation, tissue tolerance, histomorphological changes and complications of expander placement. However, only a few attempted to enhance tissue expansion. This study we aimed to evaluate verapamil, a calcium channel blocker, to enhance tissue expansion. MATERIAL AND METHOD: Twelve New Zealand rabbits weighing between 900 gm and 1200 gm were assigned into study and control groups. High volume expanders (100, 200 or 300 cc) were placed into the subcutaneous tissue. Rabbits in the study group received verapamil. Expanders in the control group were inflated every three days to achieve same pressure as the study group. The size of the flaps was assessed by applying pressure on tip of the flap to demonstrate the contraction. Histopathological examinations were performed. RESULTS: By administering liquid earlier and more quickly less flap retraction was observed in the study group. In the control group expanders were exposed in two rabbits while no complication occurred in the study group. Following extraction of the expanders, the flaps were elevated and less retraction was observed in the study group compared to controls. CONCLUSION: Verapamil is safe when used topically and provides less retracted flaps. It can be suggested that verapamil acts on the myofibroblasts in the capsule around tissue expanders and thus increases efficiency of the expanders.

No MeSH data available.


Related in: MedlinePlus

Complication in Group III: Exposed tissue expander.
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Figure 6: Complication in Group III: Exposed tissue expander.

Mentions: None of the rabbits died during the experiments. Verapamil injections were well tolerated by the rabbits and it did not cause any systemic changes or systemic or local intoxication in the rabbits. However, in the control group, one rabbit with an expander of 200 cc and one rabbit with an expander of 300 cc experienced exposition of their expanders on day 18 and 15 respectively (figure 6). No infection was detected during the procedures of expansion. However, one rabbit was observed to have immobility in his hindquarters. This may have been due to compression on the nerves.


Enhancement of Tissue Expansion by Calcium Channel Blocker: A preliminary study.

Copcu E, Sivrioglu N, Sisman N, Aktas A, Oztan Y - World J Surg Oncol (2003)

Complication in Group III: Exposed tissue expander.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC239963&req=5

Figure 6: Complication in Group III: Exposed tissue expander.
Mentions: None of the rabbits died during the experiments. Verapamil injections were well tolerated by the rabbits and it did not cause any systemic changes or systemic or local intoxication in the rabbits. However, in the control group, one rabbit with an expander of 200 cc and one rabbit with an expander of 300 cc experienced exposition of their expanders on day 18 and 15 respectively (figure 6). No infection was detected during the procedures of expansion. However, one rabbit was observed to have immobility in his hindquarters. This may have been due to compression on the nerves.

Bottom Line: Following extraction of the expanders, the flaps were elevated and less retraction was observed in the study group compared to controls.CONCLUSION: Verapamil is safe when used topically and provides less retracted flaps.It can be suggested that verapamil acts on the myofibroblasts in the capsule around tissue expanders and thus increases efficiency of the expanders.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of the Plastic and Reconstructive Surgery, Medical Faculty, Adnan Menderes University, Aydin, Turkey. copcu@lycos.com

ABSTRACT
BACKGROUND: Reconstruction of the defects after surgical resection of tumors is one of the important issues in surgical oncology. It is essential that the defect should be covered with a tissue quite similar to the original one and is best achieved by harvesting tissue from an area adjacent to the defect. Tissue expansion is one of the most frequently used reconstructive techniques. A number of studies evaluated blood circulation, capsule formation, tissue tolerance, histomorphological changes and complications of expander placement. However, only a few attempted to enhance tissue expansion. This study we aimed to evaluate verapamil, a calcium channel blocker, to enhance tissue expansion. MATERIAL AND METHOD: Twelve New Zealand rabbits weighing between 900 gm and 1200 gm were assigned into study and control groups. High volume expanders (100, 200 or 300 cc) were placed into the subcutaneous tissue. Rabbits in the study group received verapamil. Expanders in the control group were inflated every three days to achieve same pressure as the study group. The size of the flaps was assessed by applying pressure on tip of the flap to demonstrate the contraction. Histopathological examinations were performed. RESULTS: By administering liquid earlier and more quickly less flap retraction was observed in the study group. In the control group expanders were exposed in two rabbits while no complication occurred in the study group. Following extraction of the expanders, the flaps were elevated and less retraction was observed in the study group compared to controls. CONCLUSION: Verapamil is safe when used topically and provides less retracted flaps. It can be suggested that verapamil acts on the myofibroblasts in the capsule around tissue expanders and thus increases efficiency of the expanders.

No MeSH data available.


Related in: MedlinePlus