Limits...
Mitogen-activated protein kinases in normal and (pre)neoplastic ovarian surface epithelium.

Choi KC, Auersperg N, Leung PC - Reprod. Biol. Endocrinol. (2003)

Bottom Line: Mitogen-activated protein kinases (MAPKs) are a group of serine/threonine kinases which are activated in response to a diverse array of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus.It has been demonstrated that MAPKs are activated by external stimuli including chemotherapeutic agents, growth factors and reproductive hormones in ovarian surface epithelial cells.Thus, the MAPK signaling pathway may play an important role in the regulation of proliferation, survival and apoptosis in response to these external stimuli in ovarian cancer.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Obstetrics and Gynaecology, BC Children's and Women's Hospital, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V5. kchoi@cw.bc.ca

ABSTRACT
Mitogen-activated protein kinases (MAPKs) are a group of serine/threonine kinases which are activated in response to a diverse array of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus. It has been demonstrated that MAPKs are activated by external stimuli including chemotherapeutic agents, growth factors and reproductive hormones in ovarian surface epithelial cells. Thus, the MAPK signaling pathway may play an important role in the regulation of proliferation, survival and apoptosis in response to these external stimuli in ovarian cancer. In this article, an activation of the MAPK signaling cascade by several key reproductive hormones and growth factors in epithelial ovarian cancer is reviewed.

Show MeSH

Related in: MedlinePlus

Activation of the MAPK signaling pathway by FSH, ATP and GnRH in ovarian cancer.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC239898&req=5

Figure 6: Activation of the MAPK signaling pathway by FSH, ATP and GnRH in ovarian cancer.

Mentions: There is increasing evidence that the three well-characterized members of the MAPK family, ERK1/2, JNK/SAPK and p38, play an important role in the regulation of proliferation, survival and apoptosis in ovarian cancer in response to the external stimuli including hormones, growth factors, cytokines and chemotherapeutic chemicals. The signaling pathways by which hormones such as FSH, ATP and GnRH exert their effects in the regulation of cell proliferation and apoptosis in ovarian cancer cells are proposed in Fig. 6. As well, MAPK pathways may contribute to the metastasis and chemoresistance of ovarian cancer. A better understanding of the MAPK and other signaling pathways in normal and neoplastic OSE will provide new insights for the development of novel therapeutic approach to ovarian cancer.


Mitogen-activated protein kinases in normal and (pre)neoplastic ovarian surface epithelium.

Choi KC, Auersperg N, Leung PC - Reprod. Biol. Endocrinol. (2003)

Activation of the MAPK signaling pathway by FSH, ATP and GnRH in ovarian cancer.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC239898&req=5

Figure 6: Activation of the MAPK signaling pathway by FSH, ATP and GnRH in ovarian cancer.
Mentions: There is increasing evidence that the three well-characterized members of the MAPK family, ERK1/2, JNK/SAPK and p38, play an important role in the regulation of proliferation, survival and apoptosis in ovarian cancer in response to the external stimuli including hormones, growth factors, cytokines and chemotherapeutic chemicals. The signaling pathways by which hormones such as FSH, ATP and GnRH exert their effects in the regulation of cell proliferation and apoptosis in ovarian cancer cells are proposed in Fig. 6. As well, MAPK pathways may contribute to the metastasis and chemoresistance of ovarian cancer. A better understanding of the MAPK and other signaling pathways in normal and neoplastic OSE will provide new insights for the development of novel therapeutic approach to ovarian cancer.

Bottom Line: Mitogen-activated protein kinases (MAPKs) are a group of serine/threonine kinases which are activated in response to a diverse array of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus.It has been demonstrated that MAPKs are activated by external stimuli including chemotherapeutic agents, growth factors and reproductive hormones in ovarian surface epithelial cells.Thus, the MAPK signaling pathway may play an important role in the regulation of proliferation, survival and apoptosis in response to these external stimuli in ovarian cancer.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Obstetrics and Gynaecology, BC Children's and Women's Hospital, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V5. kchoi@cw.bc.ca

ABSTRACT
Mitogen-activated protein kinases (MAPKs) are a group of serine/threonine kinases which are activated in response to a diverse array of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus. It has been demonstrated that MAPKs are activated by external stimuli including chemotherapeutic agents, growth factors and reproductive hormones in ovarian surface epithelial cells. Thus, the MAPK signaling pathway may play an important role in the regulation of proliferation, survival and apoptosis in response to these external stimuli in ovarian cancer. In this article, an activation of the MAPK signaling cascade by several key reproductive hormones and growth factors in epithelial ovarian cancer is reviewed.

Show MeSH
Related in: MedlinePlus