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Interaction of Aqueous Extract of Pleurotus pulmonarius (Fr.) Quel-Champ. with Glyburide in Alloxan Induced Diabetic Mice.

Badole SL, Patel NM, Thakurdesai PA, Bodhankar SL - Evid Based Complement Alternat Med (2008)

Bottom Line: Combination of herbal drugs (or isolated phytochemicals) is found to be beneficial in certain diseases when given along with conventional drugs.Administration of PP-aqu (500 mg/kg) and its combination with glyburide (10 mg/kg) significantly (P < 0.001) decreased serum glucose level in diabetic mice.Thus we suggest that P. pulmonarius showed potent and synergistic antihyperglycemic effect in combination with glyburide.

View Article: PubMed Central - PubMed

Affiliation: Pharmacology Division, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Paud Road, Pune 411-038, India.

ABSTRACT
Mushrooms are low calorie food with very little fat and are highly suitable for obese persons. With no starch and very low sugars, they are the 'delight of the diabetics'. Combination of herbal drugs (or isolated phytochemicals) is found to be beneficial in certain diseases when given along with conventional drugs. The aim of the present study was to evaluate the effects of aqueous extract of Pleurotus pulmonarius (Lentinaceae) (called as PP-aqu) and its interaction with glyburide in alloxan induced diabetic mice. The diabetic mice treated were with PP-aqu (500 mg/kg, p.o.) alone or combination with glyburide (10 mg/kg, p.o.) for 28 days. Blood samples were collected by orbital sinus puncture using heparinized capillary glass tubes and were analyzed for serum glucose on 0, 7th, 14th, 21st and 28th days. Body weights and mortality were noted during the study period. In oral glucose tolerance test (OGTT), glucose (2.5 g/kg, p.o.) was administered with either vehicle, PP-aqu alone or in combination with glyburide and serum glucose level analyzed at 0, 30, 60 and 120 min after drug administration. Administration of PP-aqu (500 mg/kg) and its combination with glyburide (10 mg/kg) significantly (P < 0.001) decreased serum glucose level in diabetic mice. In OGTT, glyburide or PP-aqu treatment alone or their combination produced significant (P < 0.001) increase in glucose threshold. Thus we suggest that P. pulmonarius showed potent and synergistic antihyperglycemic effect in combination with glyburide.

No MeSH data available.


Related in: MedlinePlus

Effect of acute pretreatment of aqueous extract of P. pulmonarius and glyburide on serum glucose level in alloxan-induced diabetes in mice.
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Figure 1: Effect of acute pretreatment of aqueous extract of P. pulmonarius and glyburide on serum glucose level in alloxan-induced diabetes in mice.

Mentions: Figure 1 showed antihyperglycemic effects of various treatments against alloxan-induced diabetic mice. Acute administration of PP-aqu (500 mg/kg) showed peak decrease in serum glucose levels in alloxan-induced diabetic mice at 2 h (P < 0.001). However, effects gradually reduced at 4 h (P < 0.01) and 6 h (P <0.01). Glyburide (10 mg/kg) showed potent and significant effect (P < 0.001) at all time points tested. However, combination of PP-aqu (500 mg/kg) and glyburide (10 mg/kg) demonstrated sharp decrease (P < 0.001) in serum glucose levels at all the time points tested (Fig. 1).Figure 1.


Interaction of Aqueous Extract of Pleurotus pulmonarius (Fr.) Quel-Champ. with Glyburide in Alloxan Induced Diabetic Mice.

Badole SL, Patel NM, Thakurdesai PA, Bodhankar SL - Evid Based Complement Alternat Med (2008)

Effect of acute pretreatment of aqueous extract of P. pulmonarius and glyburide on serum glucose level in alloxan-induced diabetes in mice.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2396481&req=5

Figure 1: Effect of acute pretreatment of aqueous extract of P. pulmonarius and glyburide on serum glucose level in alloxan-induced diabetes in mice.
Mentions: Figure 1 showed antihyperglycemic effects of various treatments against alloxan-induced diabetic mice. Acute administration of PP-aqu (500 mg/kg) showed peak decrease in serum glucose levels in alloxan-induced diabetic mice at 2 h (P < 0.001). However, effects gradually reduced at 4 h (P < 0.01) and 6 h (P <0.01). Glyburide (10 mg/kg) showed potent and significant effect (P < 0.001) at all time points tested. However, combination of PP-aqu (500 mg/kg) and glyburide (10 mg/kg) demonstrated sharp decrease (P < 0.001) in serum glucose levels at all the time points tested (Fig. 1).Figure 1.

Bottom Line: Combination of herbal drugs (or isolated phytochemicals) is found to be beneficial in certain diseases when given along with conventional drugs.Administration of PP-aqu (500 mg/kg) and its combination with glyburide (10 mg/kg) significantly (P < 0.001) decreased serum glucose level in diabetic mice.Thus we suggest that P. pulmonarius showed potent and synergistic antihyperglycemic effect in combination with glyburide.

View Article: PubMed Central - PubMed

Affiliation: Pharmacology Division, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Paud Road, Pune 411-038, India.

ABSTRACT
Mushrooms are low calorie food with very little fat and are highly suitable for obese persons. With no starch and very low sugars, they are the 'delight of the diabetics'. Combination of herbal drugs (or isolated phytochemicals) is found to be beneficial in certain diseases when given along with conventional drugs. The aim of the present study was to evaluate the effects of aqueous extract of Pleurotus pulmonarius (Lentinaceae) (called as PP-aqu) and its interaction with glyburide in alloxan induced diabetic mice. The diabetic mice treated were with PP-aqu (500 mg/kg, p.o.) alone or combination with glyburide (10 mg/kg, p.o.) for 28 days. Blood samples were collected by orbital sinus puncture using heparinized capillary glass tubes and were analyzed for serum glucose on 0, 7th, 14th, 21st and 28th days. Body weights and mortality were noted during the study period. In oral glucose tolerance test (OGTT), glucose (2.5 g/kg, p.o.) was administered with either vehicle, PP-aqu alone or in combination with glyburide and serum glucose level analyzed at 0, 30, 60 and 120 min after drug administration. Administration of PP-aqu (500 mg/kg) and its combination with glyburide (10 mg/kg) significantly (P < 0.001) decreased serum glucose level in diabetic mice. In OGTT, glyburide or PP-aqu treatment alone or their combination produced significant (P < 0.001) increase in glucose threshold. Thus we suggest that P. pulmonarius showed potent and synergistic antihyperglycemic effect in combination with glyburide.

No MeSH data available.


Related in: MedlinePlus