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Prognostic value of genomic alterations in head and neck squamous cell carcinoma detected by comparative genomic hybridisation.

Ashman JN, Patmore HS, Condon LT, Cawkwell L, Stafford ND, Greenman J - Br. J. Cancer (2003)

Bottom Line: Kaplan-Meier survival analysis revealed significant correlations between gain of 3q25-27 and deletion of 22q with reduced disease-specific survival.In addition, gain of 17q and 20q, deletion of 19p and 22q and amplification of 11q13 were significantly associated with reduced disease-free survival.A Cox proportional hazards regression model identified deletion of 22q as an independent prognostic marker.

View Article: PubMed Central - PubMed

Affiliation: Academic Department of Otolaryngology Surgery, University of Hull, Hull HU6 7RX, UK.

ABSTRACT
A total of 45 primary head and neck squamous cell carcinomas were analysed by comparative genomic hybridisation to identify regions of chromosomal deletion and gain. Multiple regions of copy number aberration were identified including gains affecting chromosomes 3q, 8q, 5p, 7q, 12p and 11q and deletion of material from chromosomes 3p, 11q, 4p, 5q, 8p, 10q, 13q and 21. Kaplan-Meier survival analysis revealed significant correlations between gain of 3q25-27 and deletion of 22q with reduced disease-specific survival. In addition, gain of 17q and 20q, deletion of 19p and 22q and amplification of 11q13 were significantly associated with reduced disease-free survival. A Cox proportional hazards regression model identified deletion of 22q as an independent prognostic marker. The data presented here provide further evidence that the creation of a genetically based tumour classification system will soon be possible, complementing current histopathological characterisation.

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Related in: MedlinePlus

Summary of all chromosomal gains and losses identified in 45 primary HNSCC tumours by CGH. Lines to the left of the chromosome ideograms represent regions of deletion and lines to the right represent gains. The relative lengths of each line represents the size of the region of gain or loss. All CGH ratio deviations identified using the thresholds detailed in the methods were included. A few, particularly small, regions of copy number change below the accepted resolution of CGH (∼10 Mb) are present and care should be taken in interpreting these.
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fig1: Summary of all chromosomal gains and losses identified in 45 primary HNSCC tumours by CGH. Lines to the left of the chromosome ideograms represent regions of deletion and lines to the right represent gains. The relative lengths of each line represents the size of the region of gain or loss. All CGH ratio deviations identified using the thresholds detailed in the methods were included. A few, particularly small, regions of copy number change below the accepted resolution of CGH (∼10 Mb) are present and care should be taken in interpreting these.

Mentions: Genetic aberrations were detected in all 45 specimens analysed and occurred across the entire genome. Figure 1Figure 1


Prognostic value of genomic alterations in head and neck squamous cell carcinoma detected by comparative genomic hybridisation.

Ashman JN, Patmore HS, Condon LT, Cawkwell L, Stafford ND, Greenman J - Br. J. Cancer (2003)

Summary of all chromosomal gains and losses identified in 45 primary HNSCC tumours by CGH. Lines to the left of the chromosome ideograms represent regions of deletion and lines to the right represent gains. The relative lengths of each line represents the size of the region of gain or loss. All CGH ratio deviations identified using the thresholds detailed in the methods were included. A few, particularly small, regions of copy number change below the accepted resolution of CGH (∼10 Mb) are present and care should be taken in interpreting these.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2394495&req=5

fig1: Summary of all chromosomal gains and losses identified in 45 primary HNSCC tumours by CGH. Lines to the left of the chromosome ideograms represent regions of deletion and lines to the right represent gains. The relative lengths of each line represents the size of the region of gain or loss. All CGH ratio deviations identified using the thresholds detailed in the methods were included. A few, particularly small, regions of copy number change below the accepted resolution of CGH (∼10 Mb) are present and care should be taken in interpreting these.
Mentions: Genetic aberrations were detected in all 45 specimens analysed and occurred across the entire genome. Figure 1Figure 1

Bottom Line: Kaplan-Meier survival analysis revealed significant correlations between gain of 3q25-27 and deletion of 22q with reduced disease-specific survival.In addition, gain of 17q and 20q, deletion of 19p and 22q and amplification of 11q13 were significantly associated with reduced disease-free survival.A Cox proportional hazards regression model identified deletion of 22q as an independent prognostic marker.

View Article: PubMed Central - PubMed

Affiliation: Academic Department of Otolaryngology Surgery, University of Hull, Hull HU6 7RX, UK.

ABSTRACT
A total of 45 primary head and neck squamous cell carcinomas were analysed by comparative genomic hybridisation to identify regions of chromosomal deletion and gain. Multiple regions of copy number aberration were identified including gains affecting chromosomes 3q, 8q, 5p, 7q, 12p and 11q and deletion of material from chromosomes 3p, 11q, 4p, 5q, 8p, 10q, 13q and 21. Kaplan-Meier survival analysis revealed significant correlations between gain of 3q25-27 and deletion of 22q with reduced disease-specific survival. In addition, gain of 17q and 20q, deletion of 19p and 22q and amplification of 11q13 were significantly associated with reduced disease-free survival. A Cox proportional hazards regression model identified deletion of 22q as an independent prognostic marker. The data presented here provide further evidence that the creation of a genetically based tumour classification system will soon be possible, complementing current histopathological characterisation.

Show MeSH
Related in: MedlinePlus