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Glucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma?

Cooper R, Sarioğlu S, Sökmen S, Füzün M, Küpelioğlu A, Valentine H, Görken IB, Airley R, West C - Br. J. Cancer (2003)

Bottom Line: A diffuse and patchy pattern of staining, with and without colocalisation to necrosis was seen.No significant correlation was seen with other prognostic factors.In conclusion, increased GLUT-1 expression in rectal tumours was an adverse prognostic factor and is worth further evaluation as a predictive marker of response to therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Dokuz Eylül University Medical School, Inciraltu, Izmir 35340, Turkey. rachel.cooper@deu.edu.tr

ABSTRACT
The aim of the study is to evaluate the pattern and level of expression of glucose transporter-1 (GLUT-1) in rectal carcinoma in relation to outcome as a potential surrogate marker of tumour hypoxia. Formalin-fixed tumour sections from 43 patients with rectal carcinoma, who had undergone radical resection with curative intent, were immunohistochemically stained for GLUT-1. A mean of three sections per tumour (range 1-12) were examined. Each section was semiquantitatively scored; 0, no staining; 1, <10%; 2, 10-50%; 3, >50% and a score given for the whole section, the superficial (luminal) and deep (mural) part of the tumour. Staining was seen in 70% of tumours. Increased staining was noted adjacent to necrosis and ulceration. A diffuse and patchy pattern of staining, with and without colocalisation to necrosis was seen. Patients with high GLUT-1-expressing tumours (score 3 vs 0-2) had a significantly poorer overall survival (P=0.041), which was associated with poorer metastasis-free survival with no difference in local control. No significant correlation was seen with other prognostic factors. There was a strong correlation between the score for the superficial and deep parts of the tumour (r=0.81), but a significant relationship with outcome was only found in the deep part (P=0.003 vs P=0.46). In conclusion, increased GLUT-1 expression in rectal tumours was an adverse prognostic factor and is worth further evaluation as a predictive marker of response to therapy.

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Related in: MedlinePlus

Local recurrence-free survival for (A) score 0 (negative) vs 1–3 (positive) and (B) score 0–2 (negative) vs 3 (positive).
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fig4: Local recurrence-free survival for (A) score 0 (negative) vs 1–3 (positive) and (B) score 0–2 (negative) vs 3 (positive).

Mentions: Metastasis-free survival for (A) score 0 (negative) vs 1–3 (positive) and (B) score 0–2 (negative) vs 3 (positive).


Glucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma?

Cooper R, Sarioğlu S, Sökmen S, Füzün M, Küpelioğlu A, Valentine H, Görken IB, Airley R, West C - Br. J. Cancer (2003)

Local recurrence-free survival for (A) score 0 (negative) vs 1–3 (positive) and (B) score 0–2 (negative) vs 3 (positive).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2394489&req=5

fig4: Local recurrence-free survival for (A) score 0 (negative) vs 1–3 (positive) and (B) score 0–2 (negative) vs 3 (positive).
Mentions: Metastasis-free survival for (A) score 0 (negative) vs 1–3 (positive) and (B) score 0–2 (negative) vs 3 (positive).

Bottom Line: A diffuse and patchy pattern of staining, with and without colocalisation to necrosis was seen.No significant correlation was seen with other prognostic factors.In conclusion, increased GLUT-1 expression in rectal tumours was an adverse prognostic factor and is worth further evaluation as a predictive marker of response to therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Dokuz Eylül University Medical School, Inciraltu, Izmir 35340, Turkey. rachel.cooper@deu.edu.tr

ABSTRACT
The aim of the study is to evaluate the pattern and level of expression of glucose transporter-1 (GLUT-1) in rectal carcinoma in relation to outcome as a potential surrogate marker of tumour hypoxia. Formalin-fixed tumour sections from 43 patients with rectal carcinoma, who had undergone radical resection with curative intent, were immunohistochemically stained for GLUT-1. A mean of three sections per tumour (range 1-12) were examined. Each section was semiquantitatively scored; 0, no staining; 1, <10%; 2, 10-50%; 3, >50% and a score given for the whole section, the superficial (luminal) and deep (mural) part of the tumour. Staining was seen in 70% of tumours. Increased staining was noted adjacent to necrosis and ulceration. A diffuse and patchy pattern of staining, with and without colocalisation to necrosis was seen. Patients with high GLUT-1-expressing tumours (score 3 vs 0-2) had a significantly poorer overall survival (P=0.041), which was associated with poorer metastasis-free survival with no difference in local control. No significant correlation was seen with other prognostic factors. There was a strong correlation between the score for the superficial and deep parts of the tumour (r=0.81), but a significant relationship with outcome was only found in the deep part (P=0.003 vs P=0.46). In conclusion, increased GLUT-1 expression in rectal tumours was an adverse prognostic factor and is worth further evaluation as a predictive marker of response to therapy.

Show MeSH
Related in: MedlinePlus