Limits...
Nuclear expression of Survivin in paediatric ependymomas and choroid plexus tumours correlates with morphologic tumour grade.

Altura RA, Olshefski RS, Jiang Y, Boué DR - Br. J. Cancer (2003)

Bottom Line: The expression of Survivin has been associated with an adverse clinical outcome in a large number of malignancies.Prior to this report, expression within the normal human brain had not been characterised.Here, we analyse the expression of Survivin in human brain sections obtained from perinatal and paediatric autopsy cases.

View Article: PubMed Central - PubMed

Affiliation: Center for Cancer Research, Columbus Children's Research Institute, College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA. altura@pediatrics.ohio-state.edu

ABSTRACT
Survivin is a gene that is widely expressed throughout the development of the normal mammalian embryo. Subcellular localisation of Survivin to both the nucleus and cytoplasm has suggested multiple functional roles, including inhibition of cell death, especially as demonstrated within a variety of malignant cell types, as well as regulation of the mitotic spindle checkpoint. The expression of Survivin has been associated with an adverse clinical outcome in a large number of malignancies. However, nuclear Survivin expression has been described as an independent variable of favourable prognosis in two large clinical studies of breast and gastric carcinomas. Reports of Survivin expression in normal postnatal, differentiated tissues have been restricted to cell types with high proliferative capacities, including vascular endothelium, endometrium, colonic epithelium, and activated lymphocytes. Prior to this report, expression within the normal human brain had not been characterised. Here, we analyse the expression of Survivin in human brain sections obtained from perinatal and paediatric autopsy cases. We report a strikingly high level of expression of Survivin within normal ependyma and choroid plexus (CP). Analysis of corresponding neoplastic tissue in paediatric ependymomas and CP tumours shows that expression of the nuclear form of Survivin correlates with morphologic tumour grade, with a loss of nuclear expression associated with progressive cytologic anaplasia. This pattern of expression supports a hypothesis that Survivin plays a functional role in normal ependymal growth and/or neural stem cell differentiation, and that abnormally low levels of expression of the nuclear form of this protein may be a marker of more aggressive disease and/or higher morphologic grade in ependymal and CP tumours.

Show MeSH

Related in: MedlinePlus

Survivin expression in choroid plexus tumours using the sc-10811 antisera: (A) papilloma grade I, (B) atypical papilloma grade I–II (low magnification), (C) atypical papilloma grade I–II (high magnification), and (D) choroid plexus carcinoma.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2394429&req=5

fig3: Survivin expression in choroid plexus tumours using the sc-10811 antisera: (A) papilloma grade I, (B) atypical papilloma grade I–II (low magnification), (C) atypical papilloma grade I–II (high magnification), and (D) choroid plexus carcinoma.

Mentions: The results of immunohistochemical staining of CP tumours are shown in Table 1 and Figure 3Figure 3


Nuclear expression of Survivin in paediatric ependymomas and choroid plexus tumours correlates with morphologic tumour grade.

Altura RA, Olshefski RS, Jiang Y, Boué DR - Br. J. Cancer (2003)

Survivin expression in choroid plexus tumours using the sc-10811 antisera: (A) papilloma grade I, (B) atypical papilloma grade I–II (low magnification), (C) atypical papilloma grade I–II (high magnification), and (D) choroid plexus carcinoma.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2394429&req=5

fig3: Survivin expression in choroid plexus tumours using the sc-10811 antisera: (A) papilloma grade I, (B) atypical papilloma grade I–II (low magnification), (C) atypical papilloma grade I–II (high magnification), and (D) choroid plexus carcinoma.
Mentions: The results of immunohistochemical staining of CP tumours are shown in Table 1 and Figure 3Figure 3

Bottom Line: The expression of Survivin has been associated with an adverse clinical outcome in a large number of malignancies.Prior to this report, expression within the normal human brain had not been characterised.Here, we analyse the expression of Survivin in human brain sections obtained from perinatal and paediatric autopsy cases.

View Article: PubMed Central - PubMed

Affiliation: Center for Cancer Research, Columbus Children's Research Institute, College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA. altura@pediatrics.ohio-state.edu

ABSTRACT
Survivin is a gene that is widely expressed throughout the development of the normal mammalian embryo. Subcellular localisation of Survivin to both the nucleus and cytoplasm has suggested multiple functional roles, including inhibition of cell death, especially as demonstrated within a variety of malignant cell types, as well as regulation of the mitotic spindle checkpoint. The expression of Survivin has been associated with an adverse clinical outcome in a large number of malignancies. However, nuclear Survivin expression has been described as an independent variable of favourable prognosis in two large clinical studies of breast and gastric carcinomas. Reports of Survivin expression in normal postnatal, differentiated tissues have been restricted to cell types with high proliferative capacities, including vascular endothelium, endometrium, colonic epithelium, and activated lymphocytes. Prior to this report, expression within the normal human brain had not been characterised. Here, we analyse the expression of Survivin in human brain sections obtained from perinatal and paediatric autopsy cases. We report a strikingly high level of expression of Survivin within normal ependyma and choroid plexus (CP). Analysis of corresponding neoplastic tissue in paediatric ependymomas and CP tumours shows that expression of the nuclear form of Survivin correlates with morphologic tumour grade, with a loss of nuclear expression associated with progressive cytologic anaplasia. This pattern of expression supports a hypothesis that Survivin plays a functional role in normal ependymal growth and/or neural stem cell differentiation, and that abnormally low levels of expression of the nuclear form of this protein may be a marker of more aggressive disease and/or higher morphologic grade in ependymal and CP tumours.

Show MeSH
Related in: MedlinePlus