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The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements.

Todd AK, Neidle S - Nucleic Acids Res. (2008)

Bottom Line: We have carried out a survey of potential quadruplex structure sequences (PQSS), which occur in the immediate upstream region (500 bp) of human genes.By examining the number and distribution of these we have established that there is a clear link between them and the occurrence of the SP1-binding element 'GGGCGG', such that a large number of upstream PQSS incorporate the SP1-binding element.

View Article: PubMed Central - PubMed

Affiliation: CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.

ABSTRACT
We have carried out a survey of potential quadruplex structure sequences (PQSS), which occur in the immediate upstream region (500 bp) of human genes. By examining the number and distribution of these we have established that there is a clear link between them and the occurrence of the SP1-binding element 'GGGCGG', such that a large number of upstream PQSS incorporate the SP1-binding element.

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(A) SP1 sequence elements, which occur in upstream regions, (B) CCAAT sequence elements, which occur in upstream regions.
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Figure 2: (A) SP1 sequence elements, which occur in upstream regions, (B) CCAAT sequence elements, which occur in upstream regions.

Mentions: Figure 2 shows the distribution of the promoter-binding elements SP1 (GGGCGG) and CCAAT with distance from the transcription start site. The shape of this graph shows that the frequency of sequence elements rises steeply, reaching a peak in the −50 to −41 range for SP1 and in the −70 to −61 range for CCAAT before falling off gradually.Figure 2.


The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements.

Todd AK, Neidle S - Nucleic Acids Res. (2008)

(A) SP1 sequence elements, which occur in upstream regions, (B) CCAAT sequence elements, which occur in upstream regions.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2377421&req=5

Figure 2: (A) SP1 sequence elements, which occur in upstream regions, (B) CCAAT sequence elements, which occur in upstream regions.
Mentions: Figure 2 shows the distribution of the promoter-binding elements SP1 (GGGCGG) and CCAAT with distance from the transcription start site. The shape of this graph shows that the frequency of sequence elements rises steeply, reaching a peak in the −50 to −41 range for SP1 and in the −70 to −61 range for CCAAT before falling off gradually.Figure 2.

Bottom Line: We have carried out a survey of potential quadruplex structure sequences (PQSS), which occur in the immediate upstream region (500 bp) of human genes.By examining the number and distribution of these we have established that there is a clear link between them and the occurrence of the SP1-binding element 'GGGCGG', such that a large number of upstream PQSS incorporate the SP1-binding element.

View Article: PubMed Central - PubMed

Affiliation: CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.

ABSTRACT
We have carried out a survey of potential quadruplex structure sequences (PQSS), which occur in the immediate upstream region (500 bp) of human genes. By examining the number and distribution of these we have established that there is a clear link between them and the occurrence of the SP1-binding element 'GGGCGG', such that a large number of upstream PQSS incorporate the SP1-binding element.

Show MeSH