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n-3 polyunsaturated fatty acids decrease mucosal/epidermal reactions and enhance antitumour effect of ionising radiation with inhibition of tumour angiogenesis.

Wen B, Deutsch E, Opolon P, Auperin A, Frascogna V, Connault E, Bourhis J - Br. J. Cancer (2003)

Bottom Line: The effect of n-3 PUFAs was associated with inhibition of angiogenesis and tumour proliferation, and significantly decreased expression of cyclooxygenase-2.In conclusion, n-3 PUFAs administration decrease mucosal response, while moderately enhancing the antitumour effect of irradiation.The magnitude of the differential effect suggests that n-3 PUFAs need to be further investigated in the clinic.

View Article: PubMed Central - PubMed

Affiliation: Laboratoire UPRES EA No. 27-10 Radiosensibilité des tumeurs et tissus sains, Institut Gustave-Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cédex, France.

ABSTRACT
The purpose of this study was to evaluate the effect of n-3 polyunsaturated fatty acids (n-3 PUFAs) on normal tissue (lip mucosa) and tumour growth when combined with ionising radiation. The oral region (snout) of C57 black mice was irradiated with 16.5 Gy and n-3 PUFAs (100 microl) were injected intravenously for 2 weeks. After exposure to irradiation, the degree and duration of the acute reactions decreased significantly when mice were treated with n-3 PUFAs as compared to the control group. Interestingly, the range of the reactions in the n-3 PUFAs-treated group compared favourably to the group receiving amifostine (27.5 mg/kg i.v.). the effect of n-3 PUFAs was further evaluated in HEP-2 human carcinoma xenograft transplanted in nude mice. An inhibition of tumour growth was observed when mice were treated with n-3 PUFAs alone and this effect was maximal when combined with irradiation. Similar results were obtained using eicosapentaenoic acid. The effect of n-3 PUFAs was associated with inhibition of angiogenesis and tumour proliferation, and significantly decreased expression of cyclooxygenase-2. In conclusion, n-3 PUFAs administration decrease mucosal response, while moderately enhancing the antitumour effect of irradiation. The magnitude of the differential effect suggests that n-3 PUFAs need to be further investigated in the clinic.

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Related in: MedlinePlus

Change in tumour volume of tumour xenografts (HEP-2) in nude mice irradiated (RT) to a total dose of 15 Gy in two fractions of 7.5 Gy. Values at each point are the mean ratios of the observed tumour volume at a considered time divided by the initial tumour volume. Error bars represent the mean±the standard error of the ratio.
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fig3: Change in tumour volume of tumour xenografts (HEP-2) in nude mice irradiated (RT) to a total dose of 15 Gy in two fractions of 7.5 Gy. Values at each point are the mean ratios of the observed tumour volume at a considered time divided by the initial tumour volume. Error bars represent the mean±the standard error of the ratio.

Mentions: As shown in Figure 3Figure 3


n-3 polyunsaturated fatty acids decrease mucosal/epidermal reactions and enhance antitumour effect of ionising radiation with inhibition of tumour angiogenesis.

Wen B, Deutsch E, Opolon P, Auperin A, Frascogna V, Connault E, Bourhis J - Br. J. Cancer (2003)

Change in tumour volume of tumour xenografts (HEP-2) in nude mice irradiated (RT) to a total dose of 15 Gy in two fractions of 7.5 Gy. Values at each point are the mean ratios of the observed tumour volume at a considered time divided by the initial tumour volume. Error bars represent the mean±the standard error of the ratio.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2376938&req=5

fig3: Change in tumour volume of tumour xenografts (HEP-2) in nude mice irradiated (RT) to a total dose of 15 Gy in two fractions of 7.5 Gy. Values at each point are the mean ratios of the observed tumour volume at a considered time divided by the initial tumour volume. Error bars represent the mean±the standard error of the ratio.
Mentions: As shown in Figure 3Figure 3

Bottom Line: The effect of n-3 PUFAs was associated with inhibition of angiogenesis and tumour proliferation, and significantly decreased expression of cyclooxygenase-2.In conclusion, n-3 PUFAs administration decrease mucosal response, while moderately enhancing the antitumour effect of irradiation.The magnitude of the differential effect suggests that n-3 PUFAs need to be further investigated in the clinic.

View Article: PubMed Central - PubMed

Affiliation: Laboratoire UPRES EA No. 27-10 Radiosensibilité des tumeurs et tissus sains, Institut Gustave-Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cédex, France.

ABSTRACT
The purpose of this study was to evaluate the effect of n-3 polyunsaturated fatty acids (n-3 PUFAs) on normal tissue (lip mucosa) and tumour growth when combined with ionising radiation. The oral region (snout) of C57 black mice was irradiated with 16.5 Gy and n-3 PUFAs (100 microl) were injected intravenously for 2 weeks. After exposure to irradiation, the degree and duration of the acute reactions decreased significantly when mice were treated with n-3 PUFAs as compared to the control group. Interestingly, the range of the reactions in the n-3 PUFAs-treated group compared favourably to the group receiving amifostine (27.5 mg/kg i.v.). the effect of n-3 PUFAs was further evaluated in HEP-2 human carcinoma xenograft transplanted in nude mice. An inhibition of tumour growth was observed when mice were treated with n-3 PUFAs alone and this effect was maximal when combined with irradiation. Similar results were obtained using eicosapentaenoic acid. The effect of n-3 PUFAs was associated with inhibition of angiogenesis and tumour proliferation, and significantly decreased expression of cyclooxygenase-2. In conclusion, n-3 PUFAs administration decrease mucosal response, while moderately enhancing the antitumour effect of irradiation. The magnitude of the differential effect suggests that n-3 PUFAs need to be further investigated in the clinic.

Show MeSH
Related in: MedlinePlus