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Reply: Dietary acrylamide and cancer risk: additional data on coffee

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, We appreciate the comments of Drs Hagmar and Törnqvist (2003) on our article assessing dietary acrylamide and cancer risk (Mucci et al, 2003)... We undertook the original investigation in light of claims by the Swedish National Food Administration that acrylamide in foods could have global impacts on cancer incidence rates... Estimates of human cancer risk were extrapolated from animal models, given doses of acrylamide several fold higher than those to which humans are exposed (International Agency for Research on Cancer (IARC), 1994)... Notwithstanding the limitations of the risk assessment models, the authors determined an expected relative risk of 1.05 for the highest vs lowest dose... An effect estimate of this size is almost impossible to determine in any observational study... In particular, acrylamide has been detected in coffee... Although the range of exposure (∼8 μg kg) is lower than other items, coffee may account for a substantial proportion of total dose because of the frequency of consumption... Quartiles of dietary acrylamide dose were calculated based on the distribution among the controls... Adjusting for potential confounders, the risk of colorectal (Figure 2A ) and kidney cancers (Figure 2C) decreased with increasing acrylamide dose... The apparent protective effect of acrylamide parallels the lower risk associated in this study with crisp breads and for coffee, a finding consistently observed in the literature (Ekbom, 1999)... The relative risk estimate of acrylamide and bladder cancer was essentially (Figure 2B).

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Major sources of acrylamide in investigated foods in the Swedish diet, among controls.
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fig1: Major sources of acrylamide in investigated foods in the Swedish diet, among controls.

Mentions: Coffee consumption was common in this Swedish population, with 23.5% of controls consuming four or more cups of coffee per day. The daily mean (standard error) dietary acrylamide dose (μg) increased with the addition of coffee data: 34.0 (0.6) for controls, 34.8 (0.6) for colorectal, 36.8 (1.0) for bladder, and 34.5 (1.4) for kidney cancers. Crisp breads (28%) and coffee intake (20%) contributed to the largest sources of acrylamide in the diet among controls (Figure 1Figure 1


Reply: Dietary acrylamide and cancer risk: additional data on coffee
Major sources of acrylamide in investigated foods in the Swedish diet, among controls.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2376922&req=5

fig1: Major sources of acrylamide in investigated foods in the Swedish diet, among controls.
Mentions: Coffee consumption was common in this Swedish population, with 23.5% of controls consuming four or more cups of coffee per day. The daily mean (standard error) dietary acrylamide dose (μg) increased with the addition of coffee data: 34.0 (0.6) for controls, 34.8 (0.6) for colorectal, 36.8 (1.0) for bladder, and 34.5 (1.4) for kidney cancers. Crisp breads (28%) and coffee intake (20%) contributed to the largest sources of acrylamide in the diet among controls (Figure 1Figure 1

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

, We appreciate the comments of Drs Hagmar and Törnqvist (2003) on our article assessing dietary acrylamide and cancer risk (Mucci et al, 2003)... We undertook the original investigation in light of claims by the Swedish National Food Administration that acrylamide in foods could have global impacts on cancer incidence rates... Estimates of human cancer risk were extrapolated from animal models, given doses of acrylamide several fold higher than those to which humans are exposed (International Agency for Research on Cancer (IARC), 1994)... Notwithstanding the limitations of the risk assessment models, the authors determined an expected relative risk of 1.05 for the highest vs lowest dose... An effect estimate of this size is almost impossible to determine in any observational study... In particular, acrylamide has been detected in coffee... Although the range of exposure (∼8 μg kg) is lower than other items, coffee may account for a substantial proportion of total dose because of the frequency of consumption... Quartiles of dietary acrylamide dose were calculated based on the distribution among the controls... Adjusting for potential confounders, the risk of colorectal (Figure 2A ) and kidney cancers (Figure 2C) decreased with increasing acrylamide dose... The apparent protective effect of acrylamide parallels the lower risk associated in this study with crisp breads and for coffee, a finding consistently observed in the literature (Ekbom, 1999)... The relative risk estimate of acrylamide and bladder cancer was essentially (Figure 2B).

No MeSH data available.