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Impact of peritoneal cytology on survival of endometrial cancer patients treated with surgery and radiotherapy.

Tebeu PM, Popowski GY, Verkooijen HM, Casals J, Lüdicke F, Zeciri G, Usel M, Bouchardy C, Major AL - Br. J. Cancer (2003)

Bottom Line: Survival rates were analysed by Kaplan-Meier method and compared using log-rank test.The prognostic importance of peritoneal cytology was analysed by multivariate regression analysis.Histological stage IIIA patients were at increased risk to die from cancer compared to stage I patients (HR 2.7, 95% CI 1.0-7.7), while cytological stage IIIA patients were not (HR 0.3, 95% CI 0.3-2.0).

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynaecology, Geneva University Hospitals, Switzerland.

ABSTRACT
Stage IIIA endometrial cancer includes patients with serosal or adnexal invasion and patients with positive peritoneal cytology only. In this study, we assessed the impact of peritoneal cytology on endometrial cancer survival. All endometrial cancer patients receiving surgery and radiotherapy at the Geneva University Hospitals between 1980 and 1993 were included. Stage IIIA cancers were categorised into 'cytological' stage IIIA (only positive peritoneal cytology) and 'histological' stage IIIA (serosal or adnexal infiltration). Survival rates were analysed by Kaplan-Meier method and compared using log-rank test. The prognostic importance of peritoneal cytology was analysed by multivariate regression analysis. This study included 170 endometrial cancers (112 stage I, 17 cytological stage IIIA, 18 histological stage IIIA, 9 stage IIIB+). Disease-specific survival of cytological stage IIIA was not different from stage I (94 vs 88% respectively, P=0.5) but better than histological stage IIIA (94 vs 51% respectively, P<0.01). Histological stage IIIA patients were at increased risk to die from cancer compared to stage I patients (HR 2.7, 95% CI 1.0-7.7), while cytological stage IIIA patients were not (HR 0.3, 95% CI 0.3-2.0). Cytological stage IIIA endometrial cancer has similar prognosis as stage l and better prognosis than histological stage IIIA. Additional research, definitively separating stage and cytology is warranted.

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Disease-specific survival curves of endometrial cancer for the stages I, cytological IIIA and histological IIIA. Stage I=tumour confined to uterus; stage IIIA cyt=positive peritoneal cytology; stage IIIA hist=histological involvement of serosa or adnexa. Log-rank test of comparison of survival of stage I vs cytological stage IIIA: P=0.5; log-rank test of comparison of survival of cytological stage IIIA vs stage histological IIIA: P=0.008.
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fig1: Disease-specific survival curves of endometrial cancer for the stages I, cytological IIIA and histological IIIA. Stage I=tumour confined to uterus; stage IIIA cyt=positive peritoneal cytology; stage IIIA hist=histological involvement of serosa or adnexa. Log-rank test of comparison of survival of stage I vs cytological stage IIIA: P=0.5; log-rank test of comparison of survival of cytological stage IIIA vs stage histological IIIA: P=0.008.

Mentions: Death from endometrial cancer.


Impact of peritoneal cytology on survival of endometrial cancer patients treated with surgery and radiotherapy.

Tebeu PM, Popowski GY, Verkooijen HM, Casals J, Lüdicke F, Zeciri G, Usel M, Bouchardy C, Major AL - Br. J. Cancer (2003)

Disease-specific survival curves of endometrial cancer for the stages I, cytological IIIA and histological IIIA. Stage I=tumour confined to uterus; stage IIIA cyt=positive peritoneal cytology; stage IIIA hist=histological involvement of serosa or adnexa. Log-rank test of comparison of survival of stage I vs cytological stage IIIA: P=0.5; log-rank test of comparison of survival of cytological stage IIIA vs stage histological IIIA: P=0.008.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2376850&req=5

fig1: Disease-specific survival curves of endometrial cancer for the stages I, cytological IIIA and histological IIIA. Stage I=tumour confined to uterus; stage IIIA cyt=positive peritoneal cytology; stage IIIA hist=histological involvement of serosa or adnexa. Log-rank test of comparison of survival of stage I vs cytological stage IIIA: P=0.5; log-rank test of comparison of survival of cytological stage IIIA vs stage histological IIIA: P=0.008.
Mentions: Death from endometrial cancer.

Bottom Line: Survival rates were analysed by Kaplan-Meier method and compared using log-rank test.The prognostic importance of peritoneal cytology was analysed by multivariate regression analysis.Histological stage IIIA patients were at increased risk to die from cancer compared to stage I patients (HR 2.7, 95% CI 1.0-7.7), while cytological stage IIIA patients were not (HR 0.3, 95% CI 0.3-2.0).

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynaecology, Geneva University Hospitals, Switzerland.

ABSTRACT
Stage IIIA endometrial cancer includes patients with serosal or adnexal invasion and patients with positive peritoneal cytology only. In this study, we assessed the impact of peritoneal cytology on endometrial cancer survival. All endometrial cancer patients receiving surgery and radiotherapy at the Geneva University Hospitals between 1980 and 1993 were included. Stage IIIA cancers were categorised into 'cytological' stage IIIA (only positive peritoneal cytology) and 'histological' stage IIIA (serosal or adnexal infiltration). Survival rates were analysed by Kaplan-Meier method and compared using log-rank test. The prognostic importance of peritoneal cytology was analysed by multivariate regression analysis. This study included 170 endometrial cancers (112 stage I, 17 cytological stage IIIA, 18 histological stage IIIA, 9 stage IIIB+). Disease-specific survival of cytological stage IIIA was not different from stage I (94 vs 88% respectively, P=0.5) but better than histological stage IIIA (94 vs 51% respectively, P<0.01). Histological stage IIIA patients were at increased risk to die from cancer compared to stage I patients (HR 2.7, 95% CI 1.0-7.7), while cytological stage IIIA patients were not (HR 0.3, 95% CI 0.3-2.0). Cytological stage IIIA endometrial cancer has similar prognosis as stage l and better prognosis than histological stage IIIA. Additional research, definitively separating stage and cytology is warranted.

Show MeSH
Related in: MedlinePlus