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Matrix metalloproteinase-7 and matrix metalloproteinase-9 are associated with unfavourable prognosis in superficial oesophageal cancer.

Tanioka Y, Yoshida T, Yagawa T, Saiki Y, Takeo S, Harada T, Okazawa T, Yanai H, Okita K - Br. J. Cancer (2003)

Bottom Line: MMP-7 expression was significantly correlated with the presence of nodal metastasis (P=0.004).MMP-9 expression was significantly correlated with the depth of tumour invasion (P=0.004), lymphatic permeation (P=0.001), nodal metastasis (P=0.049), and pathologic differentiation grade (P=0.003).In multivariate analysis, MMP-9 expression on the invasive front was an independent prognostic indicator.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology and Hepatology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.

ABSTRACT
If oesophageal carcinoma is detected in the superficial stage, the prognosis is better than for advanced oesophageal carcinoma. But the factors which predict the prognosis and treatment policy remain unclear. Matrix metalloproteinase-7 (MMP-7) and matrix metalloproteinase-9 (MMP-9) have been reported to have close associations with tumour invasion and metastasis. In this study, we retrospectively studied the relations between MMP-7 and MMP-9 expression in immunohistochemistry, clinicopathologic factors, and prognosis in 55 superficial oesophageal carcinomas. MMP-7 and MMP-9 expression occurred in 23.6% and 47.3% of the patients, respectively. MMP-7 expression was significantly correlated with the presence of nodal metastasis (P=0.004). MMP-9 expression was significantly correlated with the depth of tumour invasion (P=0.004), lymphatic permeation (P=0.001), nodal metastasis (P=0.049), and pathologic differentiation grade (P=0.003). By the log-rank test, MMP-7 expression and MMP-9 expression on the invasive front were related to the prognosis. In multivariate analysis, MMP-9 expression on the invasive front was an independent prognostic indicator. The combined expression of MMP-7 and MMP-9 may be a good marker for the degree of malignancy of oesophageal cancer and for the presence of lymphatic metastasis.

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Comparison of overall survival curves for patients with MMP-7-positive and MMP-7-negative superficial oesophageal cancer. MMP-7-positive patients have a less favourable prognosis than those who are MMP-7-negative.
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fig2: Comparison of overall survival curves for patients with MMP-7-positive and MMP-7-negative superficial oesophageal cancer. MMP-7-positive patients have a less favourable prognosis than those who are MMP-7-negative.

Mentions: Patients with MMP-7 expression-positive cancer and MMP-9 invasive front-positive cancer had significantly shorter overall survival times than those with negative expression (P=0.025, P=0.026, respectively) (Figures 2Figure 2


Matrix metalloproteinase-7 and matrix metalloproteinase-9 are associated with unfavourable prognosis in superficial oesophageal cancer.

Tanioka Y, Yoshida T, Yagawa T, Saiki Y, Takeo S, Harada T, Okazawa T, Yanai H, Okita K - Br. J. Cancer (2003)

Comparison of overall survival curves for patients with MMP-7-positive and MMP-7-negative superficial oesophageal cancer. MMP-7-positive patients have a less favourable prognosis than those who are MMP-7-negative.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2376843&req=5

fig2: Comparison of overall survival curves for patients with MMP-7-positive and MMP-7-negative superficial oesophageal cancer. MMP-7-positive patients have a less favourable prognosis than those who are MMP-7-negative.
Mentions: Patients with MMP-7 expression-positive cancer and MMP-9 invasive front-positive cancer had significantly shorter overall survival times than those with negative expression (P=0.025, P=0.026, respectively) (Figures 2Figure 2

Bottom Line: MMP-7 expression was significantly correlated with the presence of nodal metastasis (P=0.004).MMP-9 expression was significantly correlated with the depth of tumour invasion (P=0.004), lymphatic permeation (P=0.001), nodal metastasis (P=0.049), and pathologic differentiation grade (P=0.003).In multivariate analysis, MMP-9 expression on the invasive front was an independent prognostic indicator.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology and Hepatology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.

ABSTRACT
If oesophageal carcinoma is detected in the superficial stage, the prognosis is better than for advanced oesophageal carcinoma. But the factors which predict the prognosis and treatment policy remain unclear. Matrix metalloproteinase-7 (MMP-7) and matrix metalloproteinase-9 (MMP-9) have been reported to have close associations with tumour invasion and metastasis. In this study, we retrospectively studied the relations between MMP-7 and MMP-9 expression in immunohistochemistry, clinicopathologic factors, and prognosis in 55 superficial oesophageal carcinomas. MMP-7 and MMP-9 expression occurred in 23.6% and 47.3% of the patients, respectively. MMP-7 expression was significantly correlated with the presence of nodal metastasis (P=0.004). MMP-9 expression was significantly correlated with the depth of tumour invasion (P=0.004), lymphatic permeation (P=0.001), nodal metastasis (P=0.049), and pathologic differentiation grade (P=0.003). By the log-rank test, MMP-7 expression and MMP-9 expression on the invasive front were related to the prognosis. In multivariate analysis, MMP-9 expression on the invasive front was an independent prognostic indicator. The combined expression of MMP-7 and MMP-9 may be a good marker for the degree of malignancy of oesophageal cancer and for the presence of lymphatic metastasis.

Show MeSH
Related in: MedlinePlus