Limits...
Current applications and future direction of MR mammography.

Kneeshaw PJ, Turnbull LW, Drew PJ - Br. J. Cancer (2003)

Bottom Line: Advances in both spatial and temporal resolutions, the imaging sequences employed, pharmacokinetic modelling of contrast uptake, the use of dedicated and now phased-array breast coils, and gadolinium-based contrast agents have all played their part in the advancement of this imaging technique.Despite the limitations of patient compliance, scan-time and cost, this review describes how MRM has become a valuable tool in breast disease, especially in cases of diagnostic uncertainty.However, MRM must make the transition from research institutions into routine clinical practice.

View Article: PubMed Central - PubMed

Affiliation: 1Academic Surgical Unit, Castle Hill Hospital, Castle Road, Cottingham HU 16 5JQ, UK.

ABSTRACT
Compared with triple assessment for symptomatic and occult breast disease, magnetic resonance mammography (MRM) offers higher sensitivity for the detection of multifocal cancer, which is important in selecting patients appropriately for breast-conserving surgery. It is an ideal tool for the screening of patients with a high risk of breast cancer or where there is axillary disease or nipple discharge and conventional imaging has not revealed the primary focus. Techniques are now available to biopsy lesions only apparent on MRM. MRM can differentiate scar tissue from tumour; therefore, it is useful in patients in which there is possible recurrent disease. Clinical and X-ray mammographic assessment of response to neoadjuvant chemotherapy may be unreliable because of replacement of the tumour with scar tissue. MRM can identify responders and nonresponders with more accuracy. It is the modality of choice for the assessment of breast implants for rupture with accuracy higher than X-ray mammography and ultrasound. Advances in both spatial and temporal resolutions, the imaging sequences employed, pharmacokinetic modelling of contrast uptake, the use of dedicated and now phased-array breast coils, and gadolinium-based contrast agents have all played their part in the advancement of this imaging technique. Despite the limitations of patient compliance, scan-time and cost, this review describes how MRM has become a valuable tool in breast disease, especially in cases of diagnostic uncertainty. However, MRM must make the transition from research institutions into routine clinical practice.

Show MeSH

Related in: MedlinePlus

Silicone-specific series showing an extracapsular tear with silicone globules in soft tissues.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2376788&req=5

fig6: Silicone-specific series showing an extracapsular tear with silicone globules in soft tissues.

Mentions: MRI is widely regarded as the investigation of choice for the demonstration of intracapsular and extracapsular breast implant ruptures. The sensitivity of MR for the detection of implant rupture is around 95% with a specificity of 90% and is considerably better than mammography or ultrasound (Turnbull, 2000). The intracapsular rupture is recognised by the presence of the linguine sign, which is caused by extensive folding of the collapsed shell of the implant (Gorczyca et al, 1994). Free silicone may be seen in the parenchyma of the breast following an extracapsular tear with silicone-specific MRI sequences (Figure 6Figure 6


Current applications and future direction of MR mammography.

Kneeshaw PJ, Turnbull LW, Drew PJ - Br. J. Cancer (2003)

Silicone-specific series showing an extracapsular tear with silicone globules in soft tissues.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2376788&req=5

fig6: Silicone-specific series showing an extracapsular tear with silicone globules in soft tissues.
Mentions: MRI is widely regarded as the investigation of choice for the demonstration of intracapsular and extracapsular breast implant ruptures. The sensitivity of MR for the detection of implant rupture is around 95% with a specificity of 90% and is considerably better than mammography or ultrasound (Turnbull, 2000). The intracapsular rupture is recognised by the presence of the linguine sign, which is caused by extensive folding of the collapsed shell of the implant (Gorczyca et al, 1994). Free silicone may be seen in the parenchyma of the breast following an extracapsular tear with silicone-specific MRI sequences (Figure 6Figure 6

Bottom Line: Advances in both spatial and temporal resolutions, the imaging sequences employed, pharmacokinetic modelling of contrast uptake, the use of dedicated and now phased-array breast coils, and gadolinium-based contrast agents have all played their part in the advancement of this imaging technique.Despite the limitations of patient compliance, scan-time and cost, this review describes how MRM has become a valuable tool in breast disease, especially in cases of diagnostic uncertainty.However, MRM must make the transition from research institutions into routine clinical practice.

View Article: PubMed Central - PubMed

Affiliation: 1Academic Surgical Unit, Castle Hill Hospital, Castle Road, Cottingham HU 16 5JQ, UK.

ABSTRACT
Compared with triple assessment for symptomatic and occult breast disease, magnetic resonance mammography (MRM) offers higher sensitivity for the detection of multifocal cancer, which is important in selecting patients appropriately for breast-conserving surgery. It is an ideal tool for the screening of patients with a high risk of breast cancer or where there is axillary disease or nipple discharge and conventional imaging has not revealed the primary focus. Techniques are now available to biopsy lesions only apparent on MRM. MRM can differentiate scar tissue from tumour; therefore, it is useful in patients in which there is possible recurrent disease. Clinical and X-ray mammographic assessment of response to neoadjuvant chemotherapy may be unreliable because of replacement of the tumour with scar tissue. MRM can identify responders and nonresponders with more accuracy. It is the modality of choice for the assessment of breast implants for rupture with accuracy higher than X-ray mammography and ultrasound. Advances in both spatial and temporal resolutions, the imaging sequences employed, pharmacokinetic modelling of contrast uptake, the use of dedicated and now phased-array breast coils, and gadolinium-based contrast agents have all played their part in the advancement of this imaging technique. Despite the limitations of patient compliance, scan-time and cost, this review describes how MRM has become a valuable tool in breast disease, especially in cases of diagnostic uncertainty. However, MRM must make the transition from research institutions into routine clinical practice.

Show MeSH
Related in: MedlinePlus