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Early detection of tumour immune-rejection using magnetic resonance imaging.

Hu DE, Beauregard DA, Bearchell MC, Thomsen LL, Brindle KM - Br. J. Cancer (2003)

Bottom Line: Dynamic contrast agent-enhanced magnetic resonance imaging measurements of the perfusion of an immunogenic murine tumour showed that immune rejection was preceded by an increase in the apparent vascular volume of the tumour.This increase in vascularity, which has been observed previously in other tumours undergoing immune rejection, was confirmed by histological analysis of tumour sections obtained postmortem.Magnetic resonance imaging measurements similar to this could be used in the clinic to monitor the early responses of tumours to immunotherapy, before there is any change in tumour growth rate or volume.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, University of Cambridge, UK.

ABSTRACT
Dynamic contrast agent-enhanced magnetic resonance imaging measurements of the perfusion of an immunogenic murine tumour showed that immune rejection was preceded by an increase in the apparent vascular volume of the tumour. This increase in vascularity, which has been observed previously in other tumours undergoing immune rejection, was confirmed by histological analysis of tumour sections obtained postmortem. Magnetic resonance imaging measurements similar to this could be used in the clinic to monitor the early responses of tumours to immunotherapy, before there is any change in tumour growth rate or volume.

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Time-dependent changes in signal enhancement (A) and R1p values (B) in dynamic contrast agent-enhanced T1-weighted images obtained from EL-4 (▴), progressive E.G7-OVA (▪) and regressive E.G7-OVA (•) tumours. R1p, the paramagnetic contribution to the relaxation rate, is equivalent to the contrast agent concentration. The symbols represent the mean±s.e.m. (n=5). The numbers for signal enhancement were obtained from the entire tumour cross-section. However, because of difficulties in estimating R1p values in the relatively poorly perfused regions in the centres of some tumours, these were calculated for a 20 pixel-wide band in the tumour peripheries, where vessel density was higher.
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fig4: Time-dependent changes in signal enhancement (A) and R1p values (B) in dynamic contrast agent-enhanced T1-weighted images obtained from EL-4 (▴), progressive E.G7-OVA (▪) and regressive E.G7-OVA (•) tumours. R1p, the paramagnetic contribution to the relaxation rate, is equivalent to the contrast agent concentration. The symbols represent the mean±s.e.m. (n=5). The numbers for signal enhancement were obtained from the entire tumour cross-section. However, because of difficulties in estimating R1p values in the relatively poorly perfused regions in the centres of some tumours, these were calculated for a 20 pixel-wide band in the tumour peripheries, where vessel density was higher.

Mentions: A series of T1-weighted MR images acquired from a regressive E.G7-OVA tumour (A) and an EL-4 tumour (B) following i.v. injection of the MRI contrast agent, Gd-DTPA. The first images in the series were acquired prior to contrast agent injection. The subsequent images (reading from left-to-right and top-to-bottom) were acquired at 2 min intervals. The presence of the contrast agent increases signal intensity in the images and these increases are proportional to its concentration.


Early detection of tumour immune-rejection using magnetic resonance imaging.

Hu DE, Beauregard DA, Bearchell MC, Thomsen LL, Brindle KM - Br. J. Cancer (2003)

Time-dependent changes in signal enhancement (A) and R1p values (B) in dynamic contrast agent-enhanced T1-weighted images obtained from EL-4 (▴), progressive E.G7-OVA (▪) and regressive E.G7-OVA (•) tumours. R1p, the paramagnetic contribution to the relaxation rate, is equivalent to the contrast agent concentration. The symbols represent the mean±s.e.m. (n=5). The numbers for signal enhancement were obtained from the entire tumour cross-section. However, because of difficulties in estimating R1p values in the relatively poorly perfused regions in the centres of some tumours, these were calculated for a 20 pixel-wide band in the tumour peripheries, where vessel density was higher.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2376373&req=5

fig4: Time-dependent changes in signal enhancement (A) and R1p values (B) in dynamic contrast agent-enhanced T1-weighted images obtained from EL-4 (▴), progressive E.G7-OVA (▪) and regressive E.G7-OVA (•) tumours. R1p, the paramagnetic contribution to the relaxation rate, is equivalent to the contrast agent concentration. The symbols represent the mean±s.e.m. (n=5). The numbers for signal enhancement were obtained from the entire tumour cross-section. However, because of difficulties in estimating R1p values in the relatively poorly perfused regions in the centres of some tumours, these were calculated for a 20 pixel-wide band in the tumour peripheries, where vessel density was higher.
Mentions: A series of T1-weighted MR images acquired from a regressive E.G7-OVA tumour (A) and an EL-4 tumour (B) following i.v. injection of the MRI contrast agent, Gd-DTPA. The first images in the series were acquired prior to contrast agent injection. The subsequent images (reading from left-to-right and top-to-bottom) were acquired at 2 min intervals. The presence of the contrast agent increases signal intensity in the images and these increases are proportional to its concentration.

Bottom Line: Dynamic contrast agent-enhanced magnetic resonance imaging measurements of the perfusion of an immunogenic murine tumour showed that immune rejection was preceded by an increase in the apparent vascular volume of the tumour.This increase in vascularity, which has been observed previously in other tumours undergoing immune rejection, was confirmed by histological analysis of tumour sections obtained postmortem.Magnetic resonance imaging measurements similar to this could be used in the clinic to monitor the early responses of tumours to immunotherapy, before there is any change in tumour growth rate or volume.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, University of Cambridge, UK.

ABSTRACT
Dynamic contrast agent-enhanced magnetic resonance imaging measurements of the perfusion of an immunogenic murine tumour showed that immune rejection was preceded by an increase in the apparent vascular volume of the tumour. This increase in vascularity, which has been observed previously in other tumours undergoing immune rejection, was confirmed by histological analysis of tumour sections obtained postmortem. Magnetic resonance imaging measurements similar to this could be used in the clinic to monitor the early responses of tumours to immunotherapy, before there is any change in tumour growth rate or volume.

Show MeSH
Related in: MedlinePlus