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Prognostic significance of dysadherin expression in advanced colorectal carcinoma.

Aoki S, Shimamura T, Shibata T, Nakanishi Y, Moriya Y, Sato Y, Kitajima M, Sakamoto M, Hirohashi S - Br. J. Cancer (2003)

Bottom Line: The increased expression of dysadherin was significantly associated with lung metastasis (P=0.003).The increased expression of dysadherin had a significant impact on patient survival (P=0.0099 and 0.0036, log-rank test for overall and recurrence-free survival rate, respectively).These results suggest that increased dysadherin expression is a significant indicator of poor prognosis for patients with advanced colorectal carcinoma.

View Article: PubMed Central - PubMed

Affiliation: Pathology Division, National Cancer Center Research Institute, Tokyo 1-1 Tsukiji 5-Chome, Chou-ku, Japan.

ABSTRACT
A novel glycoprotein, dysadherin, has an anti-cell - cell adhesion function through downregulating E-cadherin. In this study, we investigated the expressions of dysadherin and E-cadherin in 82 patients with stage II and III colorectal carcinomas to determine the correlation between the two molecules and the clinicopathologic features of each tumour. Dysadherin was not expressed in normal colorectal epithelium. Fifty-one per cent of tumours showed dysadherin immunopositivity in over 50% of cancer cells. Thirty-eight per cent of tumours showed reduced E-cadherin immunopositivity. The increased expression of dysadherin was significantly associated with lung metastasis (P=0.003). The increased expression of dysadherin had a significant impact on patient survival (P=0.0099 and 0.0036, log-rank test for overall and recurrence-free survival rate, respectively). Furthermore, tumour with increased expression of dysadherin and reduced expression of E-cadherin showed the worst prognosis (P=0.0043 and 0.0028, log-rank test for overall and recurrence-free survival rate, respectively). These results suggest that increased dysadherin expression is a significant indicator of poor prognosis for patients with advanced colorectal carcinoma.

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Dysadherin and E-cadherin expression in colorectal cancers demonstrated by immunohistochemistry. (A)–(D) are the adjacent sections of the same cases. (A) Dysadherin expression was observed in lymphocytes (arrowheads) and endothelial cells (arrows). Membranous dysadherin staining was localised at intercellular borders of cancer cells and was heterogeneous in tumour nests. No immunoreactivity was seen in normal colorectal epithelial cells (magnification × 200). (B) E-cadherin expression was observed at the cell–cell borders in normal epithelial cells, and was reduced in the majority of cancer cells in this section (magnification × 200). (C) Tumour cells were positively stained for dysadherin (magnification × 200). (D) E-cadherin expression was not reduced in tumour cells where dysadherin was expressed (magnification × 200). (E) Preferential dysadherin expression was observed in infiltrative tumour cells (arrow) in some cases (magnification × 200).
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fig1: Dysadherin and E-cadherin expression in colorectal cancers demonstrated by immunohistochemistry. (A)–(D) are the adjacent sections of the same cases. (A) Dysadherin expression was observed in lymphocytes (arrowheads) and endothelial cells (arrows). Membranous dysadherin staining was localised at intercellular borders of cancer cells and was heterogeneous in tumour nests. No immunoreactivity was seen in normal colorectal epithelial cells (magnification × 200). (B) E-cadherin expression was observed at the cell–cell borders in normal epithelial cells, and was reduced in the majority of cancer cells in this section (magnification × 200). (C) Tumour cells were positively stained for dysadherin (magnification × 200). (D) E-cadherin expression was not reduced in tumour cells where dysadherin was expressed (magnification × 200). (E) Preferential dysadherin expression was observed in infiltrative tumour cells (arrow) in some cases (magnification × 200).

Mentions: Dysadherin-positive staining was observed at the membranes of cancer cells, lymphocytes, and endothelial cells as previously reported (Ino et al, 2002). Membranous dysadherin staining was localised at intercellular borders of cancer cells and was heterogeneous in tumour nests. No immunoreactivity was seen in normal colorectal epithelial cells (Figure 1A, CFigure 1


Prognostic significance of dysadherin expression in advanced colorectal carcinoma.

Aoki S, Shimamura T, Shibata T, Nakanishi Y, Moriya Y, Sato Y, Kitajima M, Sakamoto M, Hirohashi S - Br. J. Cancer (2003)

Dysadherin and E-cadherin expression in colorectal cancers demonstrated by immunohistochemistry. (A)–(D) are the adjacent sections of the same cases. (A) Dysadherin expression was observed in lymphocytes (arrowheads) and endothelial cells (arrows). Membranous dysadherin staining was localised at intercellular borders of cancer cells and was heterogeneous in tumour nests. No immunoreactivity was seen in normal colorectal epithelial cells (magnification × 200). (B) E-cadherin expression was observed at the cell–cell borders in normal epithelial cells, and was reduced in the majority of cancer cells in this section (magnification × 200). (C) Tumour cells were positively stained for dysadherin (magnification × 200). (D) E-cadherin expression was not reduced in tumour cells where dysadherin was expressed (magnification × 200). (E) Preferential dysadherin expression was observed in infiltrative tumour cells (arrow) in some cases (magnification × 200).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2376346&req=5

fig1: Dysadherin and E-cadherin expression in colorectal cancers demonstrated by immunohistochemistry. (A)–(D) are the adjacent sections of the same cases. (A) Dysadherin expression was observed in lymphocytes (arrowheads) and endothelial cells (arrows). Membranous dysadherin staining was localised at intercellular borders of cancer cells and was heterogeneous in tumour nests. No immunoreactivity was seen in normal colorectal epithelial cells (magnification × 200). (B) E-cadherin expression was observed at the cell–cell borders in normal epithelial cells, and was reduced in the majority of cancer cells in this section (magnification × 200). (C) Tumour cells were positively stained for dysadherin (magnification × 200). (D) E-cadherin expression was not reduced in tumour cells where dysadherin was expressed (magnification × 200). (E) Preferential dysadherin expression was observed in infiltrative tumour cells (arrow) in some cases (magnification × 200).
Mentions: Dysadherin-positive staining was observed at the membranes of cancer cells, lymphocytes, and endothelial cells as previously reported (Ino et al, 2002). Membranous dysadherin staining was localised at intercellular borders of cancer cells and was heterogeneous in tumour nests. No immunoreactivity was seen in normal colorectal epithelial cells (Figure 1A, CFigure 1

Bottom Line: The increased expression of dysadherin was significantly associated with lung metastasis (P=0.003).The increased expression of dysadherin had a significant impact on patient survival (P=0.0099 and 0.0036, log-rank test for overall and recurrence-free survival rate, respectively).These results suggest that increased dysadherin expression is a significant indicator of poor prognosis for patients with advanced colorectal carcinoma.

View Article: PubMed Central - PubMed

Affiliation: Pathology Division, National Cancer Center Research Institute, Tokyo 1-1 Tsukiji 5-Chome, Chou-ku, Japan.

ABSTRACT
A novel glycoprotein, dysadherin, has an anti-cell - cell adhesion function through downregulating E-cadherin. In this study, we investigated the expressions of dysadherin and E-cadherin in 82 patients with stage II and III colorectal carcinomas to determine the correlation between the two molecules and the clinicopathologic features of each tumour. Dysadherin was not expressed in normal colorectal epithelium. Fifty-one per cent of tumours showed dysadherin immunopositivity in over 50% of cancer cells. Thirty-eight per cent of tumours showed reduced E-cadherin immunopositivity. The increased expression of dysadherin was significantly associated with lung metastasis (P=0.003). The increased expression of dysadherin had a significant impact on patient survival (P=0.0099 and 0.0036, log-rank test for overall and recurrence-free survival rate, respectively). Furthermore, tumour with increased expression of dysadherin and reduced expression of E-cadherin showed the worst prognosis (P=0.0043 and 0.0028, log-rank test for overall and recurrence-free survival rate, respectively). These results suggest that increased dysadherin expression is a significant indicator of poor prognosis for patients with advanced colorectal carcinoma.

Show MeSH
Related in: MedlinePlus