Induction of vasculogenesis in breast cancer models.
Bottom Line: The endothelial precursor cell population was 14% or greater in the gated lymphocyte-size fraction of the inflammatory breast cancer xenograft named WIBC-9, which exhibits a hypervascular structure and de novo formation of vascular channels, namely vasculogenic mimicry (Shirakawa et al, 2001).Furthermore, they demonstrated significantly higher levels of murine vascular endothelial growth factor and interleukin-8 in culture supernatant on time course by enzyme-linked immunosorbent assay.These findings constitute direct evidence that breast cancer induces postnatal vasculogenesis in vivo.
Affiliation: Pharmacology Division, National Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-Ku, Tokyo 104-0045, Japan. firstname.lastname@example.orgShow MeSH
Related in: MedlinePlus
Mentions: EPCs(mCD34+, mFlk-1+) in the bone marrow and peripheral blood in WIBC-9, included a large number of FLT1+(98.9%/97.5%), and TIE2+(71.8%/64.2%) but include small number of VE-cadherin (23.2%/30.6%) and CD31+(20.9%/20.9%).
Affiliation: Pharmacology Division, National Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-Ku, Tokyo 104-0045, Japan. email@example.com