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Uptake and localisation of mTHPC (Foscan) and its 14C-labelled form in normal and tumour tissues of the hamster squamous cell carcinoma model: a comparative study.

Blant SA, Glanzmann TM, Ballini JP, Wagnières G, van den Bergh H, Monnier P - Br. J. Cancer (2002)

Bottom Line: The majority of mTHPC was found at around 48 h in smooth muscle and at 96 h in healthy cheek pouch mucosa and early malignant lesions.Soon after the injection, a significant selectivity was noted for advanced squamous cell carcinoma as compared to healthy cheek pouch mucosa or striated muscle.A significant difference in mTHPC localisation and quantity was also observed between striated and smooth muscle during the first 48 h following the injection.

View Article: PubMed Central - PubMed

Affiliation: Institute of Pathology, CHUV-Hospital, Bugnon 21, CH-1011 Lausanne, Switzerland. snezana.andrejevic@chuv.hospvd.ch

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Related in: MedlinePlus

The comparative pharmacokinetics of mTHPC in healthy mucosa, early and advanced SCC observed by in situ LIFS (A), extraction of 14C-labelled mTHPC (B) and ex vivo FM (C). The photomicrographs and corresponding HE stains of healthy hamster mucosa (D), early (E) and advanced SCC (F) show high fluorescence intensity in the epithelial layers in both normal or tumoural epithelium (E), while adjacent structures such as underlying lamina propria (LP) and striated muscle (SM) show a weak fluorescence intensity. Scale: the bar in the right bottom corner represents 20 μm.
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fig4: The comparative pharmacokinetics of mTHPC in healthy mucosa, early and advanced SCC observed by in situ LIFS (A), extraction of 14C-labelled mTHPC (B) and ex vivo FM (C). The photomicrographs and corresponding HE stains of healthy hamster mucosa (D), early (E) and advanced SCC (F) show high fluorescence intensity in the epithelial layers in both normal or tumoural epithelium (E), while adjacent structures such as underlying lamina propria (LP) and striated muscle (SM) show a weak fluorescence intensity. Scale: the bar in the right bottom corner represents 20 μm.

Mentions: The comparative pharmacokinetics of mTHPC in the liver and kidney using in situ LIFS (A), extraction of 14C-labelled mTHPC (B) and ex vivo FM (C). Fluorescence photomicrographs and corresponding HE stains show the high fluorescence intensity, uniform in liver parenchyma (D) and kidney glomerulus (white areas), while a low dye amount was observed in proximal and distal tubes of kidney parenchyma (dark area) soon (24 h) after mTHPC administration (E). Scale: the bar in the right bottom corner represents 20 μm.


Uptake and localisation of mTHPC (Foscan) and its 14C-labelled form in normal and tumour tissues of the hamster squamous cell carcinoma model: a comparative study.

Blant SA, Glanzmann TM, Ballini JP, Wagnières G, van den Bergh H, Monnier P - Br. J. Cancer (2002)

The comparative pharmacokinetics of mTHPC in healthy mucosa, early and advanced SCC observed by in situ LIFS (A), extraction of 14C-labelled mTHPC (B) and ex vivo FM (C). The photomicrographs and corresponding HE stains of healthy hamster mucosa (D), early (E) and advanced SCC (F) show high fluorescence intensity in the epithelial layers in both normal or tumoural epithelium (E), while adjacent structures such as underlying lamina propria (LP) and striated muscle (SM) show a weak fluorescence intensity. Scale: the bar in the right bottom corner represents 20 μm.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2376296&req=5

fig4: The comparative pharmacokinetics of mTHPC in healthy mucosa, early and advanced SCC observed by in situ LIFS (A), extraction of 14C-labelled mTHPC (B) and ex vivo FM (C). The photomicrographs and corresponding HE stains of healthy hamster mucosa (D), early (E) and advanced SCC (F) show high fluorescence intensity in the epithelial layers in both normal or tumoural epithelium (E), while adjacent structures such as underlying lamina propria (LP) and striated muscle (SM) show a weak fluorescence intensity. Scale: the bar in the right bottom corner represents 20 μm.
Mentions: The comparative pharmacokinetics of mTHPC in the liver and kidney using in situ LIFS (A), extraction of 14C-labelled mTHPC (B) and ex vivo FM (C). Fluorescence photomicrographs and corresponding HE stains show the high fluorescence intensity, uniform in liver parenchyma (D) and kidney glomerulus (white areas), while a low dye amount was observed in proximal and distal tubes of kidney parenchyma (dark area) soon (24 h) after mTHPC administration (E). Scale: the bar in the right bottom corner represents 20 μm.

Bottom Line: The majority of mTHPC was found at around 48 h in smooth muscle and at 96 h in healthy cheek pouch mucosa and early malignant lesions.Soon after the injection, a significant selectivity was noted for advanced squamous cell carcinoma as compared to healthy cheek pouch mucosa or striated muscle.A significant difference in mTHPC localisation and quantity was also observed between striated and smooth muscle during the first 48 h following the injection.

View Article: PubMed Central - PubMed

Affiliation: Institute of Pathology, CHUV-Hospital, Bugnon 21, CH-1011 Lausanne, Switzerland. snezana.andrejevic@chuv.hospvd.ch

Show MeSH
Related in: MedlinePlus