Uptake and localisation of mTHPC (Foscan) and its 14C-labelled form in normal and tumour tissues of the hamster squamous cell carcinoma model: a comparative study.
Bottom Line: The majority of mTHPC was found at around 48 h in smooth muscle and at 96 h in healthy cheek pouch mucosa and early malignant lesions.Soon after the injection, a significant selectivity was noted for advanced squamous cell carcinoma as compared to healthy cheek pouch mucosa or striated muscle.A significant difference in mTHPC localisation and quantity was also observed between striated and smooth muscle during the first 48 h following the injection.
Affiliation: Institute of Pathology, CHUV-Hospital, Bugnon 21, CH-1011 Lausanne, Switzerland. email@example.comShow MeSH
Related in: MedlinePlus
Mentions: Female Syrian hamsters (BRL, Fuellinsdorf, CH) weighing 140–160 g, housed at room temperature with 12 h light/dark cycle were used in this study. Free access to food and drinking water was allowed throughout the experiments. The animals were divided into two groups (early and advanced SCC) prior to chemically induced carcinogenesis. Early and advanced SCCs were chemically induced by topical application of 5% oily DMBA (Sigma Chemicals, Co., St. Louis, MO, USA) solution in the hamster's left cheek pouch mucosa three times weekly during 10–12 weeks (early SCC) and 14–16 weeks (advanced SCC), respectively. The contralateral buccal pouch mucosa, which was not painted with DMBA, served as the healthy mucosa control (Figure 1AFigure 1
Affiliation: Institute of Pathology, CHUV-Hospital, Bugnon 21, CH-1011 Lausanne, Switzerland. firstname.lastname@example.org