Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition.
Bottom Line: For the micronucleus assay lymphocytes were exposed in vitro to 3.5 Gy (60)Co gamma-rays at a high dose rate or low dose rate. 70 h post-irradiation cultures were arrested and micronuclei were scored in 1000 binucleate cells.A higher proportion of the patients were radiosensitive with the micronucleus assay (45% with high dose rate and 61% with low dose rate).No correlation was found between the G2 and the G0-micronucleus chromosomal radiosensitivity.
Affiliation: Department of Anatomy, University of Gent, L. Pasteurlaan 2, B-9000 Gent, Belgium.Show MeSH
Related in: MedlinePlus
Mentions: To investigate the correlation between the different assays for radiosensitivity of the patient group the Pearson correlation coefficient was calculated. A poor correlation was found between G2 and G0 sensitivity using the same blood sample for both assays: G2 – HDR MN r=0.04 and G2 – LDR MN r=0.05. Only 14% of the patients were sensitive in the three assays (G2, HDR- and LDR MN). A good correlation was only obtained between the HDR MN and the LDR MN assay (r=0.46); 32% of the patients were sensitive in both assays (Figure 4Figure 4
Affiliation: Department of Anatomy, University of Gent, L. Pasteurlaan 2, B-9000 Gent, Belgium.