Limits...
Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition.

Baeyens A, Thierens H, Claes K, Poppe B, Messiaen L, De Ridder L, Vral A - Br. J. Cancer (2002)

Bottom Line: For the micronucleus assay lymphocytes were exposed in vitro to 3.5 Gy (60)Co gamma-rays at a high dose rate or low dose rate. 70 h post-irradiation cultures were arrested and micronuclei were scored in 1000 binucleate cells.A higher proportion of the patients were radiosensitive with the micronucleus assay (45% with high dose rate and 61% with low dose rate).No correlation was found between the G2 and the G0-micronucleus chromosomal radiosensitivity.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, University of Gent, L. Pasteurlaan 2, B-9000 Gent, Belgium.

Show MeSH

Related in: MedlinePlus

Correlation between induced MN yields after HDR and after LDR irradiation for breast cancer patients. The vertical line represents the cut-off point between sensitive/non-sensitive after HDR irradiation and the horizontal line represents the cut-off point between sensitive/non-sensitive after LDR irradiation.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2376291&req=5

fig4: Correlation between induced MN yields after HDR and after LDR irradiation for breast cancer patients. The vertical line represents the cut-off point between sensitive/non-sensitive after HDR irradiation and the horizontal line represents the cut-off point between sensitive/non-sensitive after LDR irradiation.

Mentions: To investigate the correlation between the different assays for radiosensitivity of the patient group the Pearson correlation coefficient was calculated. A poor correlation was found between G2 and G0 sensitivity using the same blood sample for both assays: G2 – HDR MN r=0.04 and G2 – LDR MN r=0.05. Only 14% of the patients were sensitive in the three assays (G2, HDR- and LDR MN). A good correlation was only obtained between the HDR MN and the LDR MN assay (r=0.46); 32% of the patients were sensitive in both assays (Figure 4Figure 4


Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition.

Baeyens A, Thierens H, Claes K, Poppe B, Messiaen L, De Ridder L, Vral A - Br. J. Cancer (2002)

Correlation between induced MN yields after HDR and after LDR irradiation for breast cancer patients. The vertical line represents the cut-off point between sensitive/non-sensitive after HDR irradiation and the horizontal line represents the cut-off point between sensitive/non-sensitive after LDR irradiation.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2376291&req=5

fig4: Correlation between induced MN yields after HDR and after LDR irradiation for breast cancer patients. The vertical line represents the cut-off point between sensitive/non-sensitive after HDR irradiation and the horizontal line represents the cut-off point between sensitive/non-sensitive after LDR irradiation.
Mentions: To investigate the correlation between the different assays for radiosensitivity of the patient group the Pearson correlation coefficient was calculated. A poor correlation was found between G2 and G0 sensitivity using the same blood sample for both assays: G2 – HDR MN r=0.04 and G2 – LDR MN r=0.05. Only 14% of the patients were sensitive in the three assays (G2, HDR- and LDR MN). A good correlation was only obtained between the HDR MN and the LDR MN assay (r=0.46); 32% of the patients were sensitive in both assays (Figure 4Figure 4

Bottom Line: For the micronucleus assay lymphocytes were exposed in vitro to 3.5 Gy (60)Co gamma-rays at a high dose rate or low dose rate. 70 h post-irradiation cultures were arrested and micronuclei were scored in 1000 binucleate cells.A higher proportion of the patients were radiosensitive with the micronucleus assay (45% with high dose rate and 61% with low dose rate).No correlation was found between the G2 and the G0-micronucleus chromosomal radiosensitivity.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, University of Gent, L. Pasteurlaan 2, B-9000 Gent, Belgium.

Show MeSH
Related in: MedlinePlus