Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition.
Bottom Line: For the micronucleus assay lymphocytes were exposed in vitro to 3.5 Gy (60)Co gamma-rays at a high dose rate or low dose rate. 70 h post-irradiation cultures were arrested and micronuclei were scored in 1000 binucleate cells.A higher proportion of the patients were radiosensitive with the micronucleus assay (45% with high dose rate and 61% with low dose rate).No correlation was found between the G2 and the G0-micronucleus chromosomal radiosensitivity.
Affiliation: Department of Anatomy, University of Gent, L. Pasteurlaan 2, B-9000 Gent, Belgium.Show MeSH
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Mentions: Radiation induced micronucleus yields after HDR irradiation for normal healthy donors (Controls), all breast cancer patients (Patients), breast cancer patients with a BRCA1/2 mutation (BRCA), and breast cancer patients younger than 35 without a family history (Y). The vertical line represents the cut-off point between sensitive/non-sensitive.
Affiliation: Department of Anatomy, University of Gent, L. Pasteurlaan 2, B-9000 Gent, Belgium.