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Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition.

Baeyens A, Thierens H, Claes K, Poppe B, Messiaen L, De Ridder L, Vral A - Br. J. Cancer (2002)

Bottom Line: For the micronucleus assay lymphocytes were exposed in vitro to 3.5 Gy (60)Co gamma-rays at a high dose rate or low dose rate. 70 h post-irradiation cultures were arrested and micronuclei were scored in 1000 binucleate cells.A higher proportion of the patients were radiosensitive with the micronucleus assay (45% with high dose rate and 61% with low dose rate).No correlation was found between the G2 and the G0-micronucleus chromosomal radiosensitivity.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, University of Gent, L. Pasteurlaan 2, B-9000 Gent, Belgium.

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Related in: MedlinePlus

Radiation induced micronucleus yields after LDR irradiation for normal healthy donors (Controls), all breast cancer patients (Patients), breast cancer patients with a BRCA1/2 mutation (BRCA), and breast cancer patients younger than 35 without a family history (Y). The vertical line represents the cut-off point between sensitive/non-sensitive.
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fig3: Radiation induced micronucleus yields after LDR irradiation for normal healthy donors (Controls), all breast cancer patients (Patients), breast cancer patients with a BRCA1/2 mutation (BRCA), and breast cancer patients younger than 35 without a family history (Y). The vertical line represents the cut-off point between sensitive/non-sensitive.

Mentions: Radiation induced micronucleus yields after HDR irradiation for normal healthy donors (Controls), all breast cancer patients (Patients), breast cancer patients with a BRCA1/2 mutation (BRCA), and breast cancer patients younger than 35 without a family history (Y). The vertical line represents the cut-off point between sensitive/non-sensitive.


Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition.

Baeyens A, Thierens H, Claes K, Poppe B, Messiaen L, De Ridder L, Vral A - Br. J. Cancer (2002)

Radiation induced micronucleus yields after LDR irradiation for normal healthy donors (Controls), all breast cancer patients (Patients), breast cancer patients with a BRCA1/2 mutation (BRCA), and breast cancer patients younger than 35 without a family history (Y). The vertical line represents the cut-off point between sensitive/non-sensitive.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2376291&req=5

fig3: Radiation induced micronucleus yields after LDR irradiation for normal healthy donors (Controls), all breast cancer patients (Patients), breast cancer patients with a BRCA1/2 mutation (BRCA), and breast cancer patients younger than 35 without a family history (Y). The vertical line represents the cut-off point between sensitive/non-sensitive.
Mentions: Radiation induced micronucleus yields after HDR irradiation for normal healthy donors (Controls), all breast cancer patients (Patients), breast cancer patients with a BRCA1/2 mutation (BRCA), and breast cancer patients younger than 35 without a family history (Y). The vertical line represents the cut-off point between sensitive/non-sensitive.

Bottom Line: For the micronucleus assay lymphocytes were exposed in vitro to 3.5 Gy (60)Co gamma-rays at a high dose rate or low dose rate. 70 h post-irradiation cultures were arrested and micronuclei were scored in 1000 binucleate cells.A higher proportion of the patients were radiosensitive with the micronucleus assay (45% with high dose rate and 61% with low dose rate).No correlation was found between the G2 and the G0-micronucleus chromosomal radiosensitivity.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, University of Gent, L. Pasteurlaan 2, B-9000 Gent, Belgium.

Show MeSH
Related in: MedlinePlus