Multivariate regression analyses of data from a randomised, double-blind, placebo-controlled study confirm quality of life benefit of epoetin alfa in patients receiving non-platinum chemotherapy.
Bottom Line: Cancer-related anaemia is associated with a wide spectrum of symptoms that can negatively affect quality of life.The a priori-planned multiple linear regression analysis, which accounted for the effects of disease progression and several other possibly confounding variables on quality of life, showed a significant advantage for epoetin alfa over placebo for the five scales (all, P<0.05), and confirmed the results of the univariate analysis.For cancer-specific measures, significant correlations were demonstrated between baseline haemoglobin and quality of life (r, range: 0.14-0.26, all P<0.05) and between change in haemoglobin and change in quality of life (r, range: 0.26-0.34, all P<0.01).
Affiliation: Cancer Research UK Psychosocial Oncology Group, Brighton and Sussex Medical School, University of Sussex, Brighton, BN1 9QG, UK. firstname.lastname@example.orgShow MeSH
Related in: MedlinePlus
Mentions: Correlation analyses were performed to examine the relationship between Hb level and QoL (Table 7Table 7Correlation between haemoglobin level and QoL scores). Positive cross-sectional correlations were found for every scale except the SF-36 MCS scale. Slightly stronger longitudinal correlations were found using all seven primary QoL scales; all P values were significant (range, P<0.01 to P=0.03). Figure 7Figure 7
Affiliation: Cancer Research UK Psychosocial Oncology Group, Brighton and Sussex Medical School, University of Sussex, Brighton, BN1 9QG, UK. email@example.com