Multivariate regression analyses of data from a randomised, double-blind, placebo-controlled study confirm quality of life benefit of epoetin alfa in patients receiving non-platinum chemotherapy.
Bottom Line: Results of the univariate analysis have been reported previously.The a priori-planned multiple linear regression analysis, which accounted for the effects of disease progression and several other possibly confounding variables on quality of life, showed a significant advantage for epoetin alfa over placebo for the five scales (all, P<0.05), and confirmed the results of the univariate analysis.These findings provide evidence that increasing haemoglobin levels by epoetin alfa administration can significantly improve cancer patients' quality of life.
Affiliation: Cancer Research UK Psychosocial Oncology Group, Brighton and Sussex Medical School, University of Sussex, Brighton, BN1 9QG, UK. firstname.lastname@example.orgShow MeSH
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Mentions: Patients self-administered the three QoL questionnaires as a single packet a maximum of four times during the study: (1) pretreatment (at the time of randomisation to either epoetin alfa or placebo); (2) before the start of the second on-study chemotherapy cycle for patients on a cyclic chemotherapy regimen (or approximately week 4); (3) before the start of the fifth on-study chemotherapy cycle (or approximately week 16); and (4) at study completion (within 5 days of study completion or at the time of early withdrawal) (Figure 1Figure 1
Affiliation: Cancer Research UK Psychosocial Oncology Group, Brighton and Sussex Medical School, University of Sussex, Brighton, BN1 9QG, UK. email@example.com