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Intense inflammation in bladder carcinoma is associated with angiogenesis and indicates good prognosis.

Offersen BV, Knap MM, Marcussen N, Horsman MR, Hamilton-Dutoit S, Overgaard J - Br. J. Cancer (2002)

Bottom Line: Areas of minimal, moderate and intense inflammation were found in 48, 92 and 32 tumours.High microvessel density, irrespective of the degree of inflammation, was associated with a significantly better disease-specific survival (P=0.01).In conclusion, inflammation was significantly correlated to microvessel density, and areas of intense inflammation were an independent marker of good prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Experimental Clinical Oncology, Danish Cancer Society, Aarhus University Hospital, Noerrebrogade 44, bldg 5, DK-8000 Aarhus C, Denmark. bvo@oncology.dk

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(A–C) Shows examples of minimal, moderate and intense inflammation, respectively. CD34-positive vessels are highlighted with red and counterstained with haematoxylin. Notice in C carcinoma cells lying in close relation to the inflammatory cells. (D) Shows VEGF staining of an adjacent section to B. Notice the intense staining of inflammatory cells in the stroma and of the carcinoma cells. Bar is 100 μm.
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fig3: (A–C) Shows examples of minimal, moderate and intense inflammation, respectively. CD34-positive vessels are highlighted with red and counterstained with haematoxylin. Notice in C carcinoma cells lying in close relation to the inflammatory cells. (D) Shows VEGF staining of an adjacent section to B. Notice the intense staining of inflammatory cells in the stroma and of the carcinoma cells. Bar is 100 μm.

Mentions: Forty-eight of the tumours (45%) had areas in the invasive carcinoma with minimal associated inflammation (Figure 3AFigure 3


Intense inflammation in bladder carcinoma is associated with angiogenesis and indicates good prognosis.

Offersen BV, Knap MM, Marcussen N, Horsman MR, Hamilton-Dutoit S, Overgaard J - Br. J. Cancer (2002)

(A–C) Shows examples of minimal, moderate and intense inflammation, respectively. CD34-positive vessels are highlighted with red and counterstained with haematoxylin. Notice in C carcinoma cells lying in close relation to the inflammatory cells. (D) Shows VEGF staining of an adjacent section to B. Notice the intense staining of inflammatory cells in the stroma and of the carcinoma cells. Bar is 100 μm.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2376289&req=5

fig3: (A–C) Shows examples of minimal, moderate and intense inflammation, respectively. CD34-positive vessels are highlighted with red and counterstained with haematoxylin. Notice in C carcinoma cells lying in close relation to the inflammatory cells. (D) Shows VEGF staining of an adjacent section to B. Notice the intense staining of inflammatory cells in the stroma and of the carcinoma cells. Bar is 100 μm.
Mentions: Forty-eight of the tumours (45%) had areas in the invasive carcinoma with minimal associated inflammation (Figure 3AFigure 3

Bottom Line: Areas of minimal, moderate and intense inflammation were found in 48, 92 and 32 tumours.High microvessel density, irrespective of the degree of inflammation, was associated with a significantly better disease-specific survival (P=0.01).In conclusion, inflammation was significantly correlated to microvessel density, and areas of intense inflammation were an independent marker of good prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Experimental Clinical Oncology, Danish Cancer Society, Aarhus University Hospital, Noerrebrogade 44, bldg 5, DK-8000 Aarhus C, Denmark. bvo@oncology.dk

Show MeSH
Related in: MedlinePlus