15-PGJ2, but not thiazolidinediones, inhibits cell growth, induces apoptosis, and causes downregulation of Stat3 in human oral SCCa cells.
Bottom Line: Interestingly, rosiglitazone and ciglitazone, two members of the thiazolidinedione family of PPARgamma activators, did not exert a growth inhibitory effect.In contrast, other PPARgamma did not induce similar effects.Our results provide the first evidence of significant antineoplastic effects of 15-PGJ(2) on human oral squamous cell carcinoma cells, which may be related to downmodulation of Stat3 and are at least partly mediated through PPARgamma-independent events.
Affiliation: Department of Diagnostic Sciences and Pathology, University of Maryland, 666 W. Baltimore Street, Room 4-C-02, Baltimore, MD 21201, USA. email@example.comShow MeSH
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Mentions: Quantitative RT–PCR analysis showed mRNA expression for PPARγ in all four oral SCCa cell lines. The lowest levels of PPARγ mRNA were expressed in SCC25 and the highest in SCC9 (Table 1Table 1Relative PPARγ mRNA expression in oral SCCa cell linesa). Protein expression of PPARγ was detected by means of immunocytochemistry; PPARγ immunostaining, primarily in a cytoplasmic location, was evident in all four oral SCCa cell lines (Figure 1A,BFigure 1
Affiliation: Department of Diagnostic Sciences and Pathology, University of Maryland, 666 W. Baltimore Street, Room 4-C-02, Baltimore, MD 21201, USA. firstname.lastname@example.org