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Nifedipine improves blood flow and oxygen supply, but not steady-state oxygenation of tumours in perfusion pressure-controlled isolated limb perfusion.

Thews O, Hummel M, Kelleher DK, Lecher B, Vaupel P - Br. J. Cancer (2002)

Bottom Line: Perfusion was performed by cannulation of the femoral artery and vein in rats bearing DS-sarcoma on the hind foot dorsum.Following equilibration, nifedipine was continuously infused for 30 min (8.3 microg min(-1) kg(-1) BW).Despite the increased oxygen availability (+63%) seen upon application of this calcium channel blocker, nifedipine does not result in a substantial reduction of tumour hypoxia, most probably due to an increase in O(2) uptake with rising O(2) supply to the tumour-bearing hind limb.

View Article: PubMed Central - PubMed

Affiliation: Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany. OLTHEWS@uni-mainz.de

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Correlation between O2 supply and O2 uptake during isolated limb perfusion.
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fig5: Correlation between O2 supply and O2 uptake during isolated limb perfusion.

Mentions: Changes of mean tumour pO2 during isolated limb perfusion upon application of nifedipine compared to the pO2 value immediately prior to the commencement of drug infusion. Data represent mean±s.e.m. (n=number of tumours investigated).


Nifedipine improves blood flow and oxygen supply, but not steady-state oxygenation of tumours in perfusion pressure-controlled isolated limb perfusion.

Thews O, Hummel M, Kelleher DK, Lecher B, Vaupel P - Br. J. Cancer (2002)

Correlation between O2 supply and O2 uptake during isolated limb perfusion.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2376281&req=5

fig5: Correlation between O2 supply and O2 uptake during isolated limb perfusion.
Mentions: Changes of mean tumour pO2 during isolated limb perfusion upon application of nifedipine compared to the pO2 value immediately prior to the commencement of drug infusion. Data represent mean±s.e.m. (n=number of tumours investigated).

Bottom Line: Perfusion was performed by cannulation of the femoral artery and vein in rats bearing DS-sarcoma on the hind foot dorsum.Following equilibration, nifedipine was continuously infused for 30 min (8.3 microg min(-1) kg(-1) BW).Despite the increased oxygen availability (+63%) seen upon application of this calcium channel blocker, nifedipine does not result in a substantial reduction of tumour hypoxia, most probably due to an increase in O(2) uptake with rising O(2) supply to the tumour-bearing hind limb.

View Article: PubMed Central - PubMed

Affiliation: Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany. OLTHEWS@uni-mainz.de

Show MeSH
Related in: MedlinePlus