Nifedipine improves blood flow and oxygen supply, but not steady-state oxygenation of tumours in perfusion pressure-controlled isolated limb perfusion.
Bottom Line: Perfusion was performed by cannulation of the femoral artery and vein in rats bearing DS-sarcoma on the hind foot dorsum.Following equilibration, nifedipine was continuously infused for 30 min (8.3 microg min(-1) kg(-1) BW).Despite the increased oxygen availability (+63%) seen upon application of this calcium channel blocker, nifedipine does not result in a substantial reduction of tumour hypoxia, most probably due to an increase in O(2) uptake with rising O(2) supply to the tumour-bearing hind limb.
Affiliation: Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany. OLTHEWS@uni-mainz.deShow MeSH
Related in: MedlinePlus
Mentions: Changes of mean tumour pO2 during isolated limb perfusion upon application of nifedipine compared to the pO2 value immediately prior to the commencement of drug infusion. Data represent mean±s.e.m. (n=number of tumours investigated).
Affiliation: Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany. OLTHEWS@uni-mainz.de