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Nifedipine improves blood flow and oxygen supply, but not steady-state oxygenation of tumours in perfusion pressure-controlled isolated limb perfusion.

Thews O, Hummel M, Kelleher DK, Lecher B, Vaupel P - Br. J. Cancer (2002)

Bottom Line: Perfusion was performed by cannulation of the femoral artery and vein in rats bearing DS-sarcoma on the hind foot dorsum.Following equilibration, nifedipine was continuously infused for 30 min (8.3 microg min(-1) kg(-1) BW).Despite the increased oxygen availability (+63%) seen upon application of this calcium channel blocker, nifedipine does not result in a substantial reduction of tumour hypoxia, most probably due to an increase in O(2) uptake with rising O(2) supply to the tumour-bearing hind limb.

View Article: PubMed Central - PubMed

Affiliation: Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany. OLTHEWS@uni-mainz.de

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Changes of mean tumour pO2 during isolated limb perfusion upon application of nifedipine compared to the pO2 value immediately prior to the commencement of drug infusion. Data represent mean±s.e.m. (n=number of tumours investigated).
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fig4: Changes of mean tumour pO2 during isolated limb perfusion upon application of nifedipine compared to the pO2 value immediately prior to the commencement of drug infusion. Data represent mean±s.e.m. (n=number of tumours investigated).

Mentions: Since the oxygen content of the arterial perfusate was maintained by oxygenising the blood with a capillary oxygenator to give an oxyhaemoglobin saturation of almost 100%, the increase in perfusate flow rate during nifedipine application resulted in a pronounced increase in O2 delivery to the perfused limb. However, the improved supply had only a minor impact on the O2 partial pressure of the tumour tissue. Figure 4Figure 4


Nifedipine improves blood flow and oxygen supply, but not steady-state oxygenation of tumours in perfusion pressure-controlled isolated limb perfusion.

Thews O, Hummel M, Kelleher DK, Lecher B, Vaupel P - Br. J. Cancer (2002)

Changes of mean tumour pO2 during isolated limb perfusion upon application of nifedipine compared to the pO2 value immediately prior to the commencement of drug infusion. Data represent mean±s.e.m. (n=number of tumours investigated).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2376281&req=5

fig4: Changes of mean tumour pO2 during isolated limb perfusion upon application of nifedipine compared to the pO2 value immediately prior to the commencement of drug infusion. Data represent mean±s.e.m. (n=number of tumours investigated).
Mentions: Since the oxygen content of the arterial perfusate was maintained by oxygenising the blood with a capillary oxygenator to give an oxyhaemoglobin saturation of almost 100%, the increase in perfusate flow rate during nifedipine application resulted in a pronounced increase in O2 delivery to the perfused limb. However, the improved supply had only a minor impact on the O2 partial pressure of the tumour tissue. Figure 4Figure 4

Bottom Line: Perfusion was performed by cannulation of the femoral artery and vein in rats bearing DS-sarcoma on the hind foot dorsum.Following equilibration, nifedipine was continuously infused for 30 min (8.3 microg min(-1) kg(-1) BW).Despite the increased oxygen availability (+63%) seen upon application of this calcium channel blocker, nifedipine does not result in a substantial reduction of tumour hypoxia, most probably due to an increase in O(2) uptake with rising O(2) supply to the tumour-bearing hind limb.

View Article: PubMed Central - PubMed

Affiliation: Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany. OLTHEWS@uni-mainz.de

Show MeSH
Related in: MedlinePlus