Prediction of outcome in locally advanced breast cancer by post-chemotherapy nodal status and baseline serum tumour markers.
Bottom Line: At a median follow-up of 57 months, the 5-year overall survival for the entire group and the disease-free survival for the 94 operated patients were 65% and 53%, respectively.Univariate analysis identified 10 prognostic factors of overall and disease-free survival, of which four retained significance on multivariate analysis: inflammatory breast cancer (P=0.0000, P=0.0004, respectively), baseline tumour markers (P=0.003 for both), post-chemotherapy number of involved nodes (P=0.003; P=0.017) and extracapsular spread (P=0.052; P=0.014).In conclusion, besides inflammatory features, baseline tumour markers and post-chemotherapy nodal status are strong predictors of outcome in locally advanced breast cancer.
Affiliation: Institute of Oncology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel. email@example.comShow MeSH
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Mentions: The univariate analysis of the pretreatment clinical prognostic factors is shown in Table 2Table 2Survival by pretreatment characteristics: Univariate analysis. Four factors were found to significantly correlate with poorer outcome (OS and DFS): clinical tumour size larger than 5 cm, inflammatory features, high grade, and elevated levels of baseline markers. Inflammatory carcinoma had the strongest impact, decreasing the estimated 5-year OS from 79 to 27% (Figure 1Figure 1
Affiliation: Institute of Oncology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel. firstname.lastname@example.org