Arterio-venous gradients of IL-6, plasma and serum VEGF and D-dimers in human cancer.
Bottom Line: In the megakaryoblastic cell line MEG-01, the expression of vascular endothelial growth factor-A was found to be regulated by interleukin-6.Our results suggest a pivotal role for interleukin-6 in the intrinsic link between haemostasis and angiogenesis.This might be of importance in the development of anti-angiogenic agents based on interference with haemostasis.
Affiliation: Angiogenesis Group, Oncology Center, St.-Augustinus Hospital, Oosterveldlaan 24, 2610 Wilrijk, Belgium.Show MeSH
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Mentions: A correlation was observed between circulating IL-6 (6.9±9.7 pg ml−1), and platelet count in the peripheral venous circulation in all patients without metastasis (r=0.54; P=0.04; Figure 3AFigure 3
Affiliation: Angiogenesis Group, Oncology Center, St.-Augustinus Hospital, Oosterveldlaan 24, 2610 Wilrijk, Belgium.