Arterio-venous gradients of IL-6, plasma and serum VEGF and D-dimers in human cancer.
Bottom Line: In the megakaryoblastic cell line MEG-01, the expression of vascular endothelial growth factor-A was found to be regulated by interleukin-6.Our results suggest a pivotal role for interleukin-6 in the intrinsic link between haemostasis and angiogenesis.This might be of importance in the development of anti-angiogenic agents based on interference with haemostasis.
Affiliation: Angiogenesis Group, Oncology Center, St.-Augustinus Hospital, Oosterveldlaan 24, 2610 Wilrijk, Belgium.Show MeSH
Related in: MedlinePlus
Mentions: (A) VEGF-immunoreactivity in colorectal tumour cells (arrows ×400). (B) Interleukin-6-immunoreactivity in colorectal tumour cells (arrow ×400). (C) Adherence, aggregation and extravasation of platelets (thin arrows) in the vicinity of colorectal tumour cells (thick arrows ×400). (D) Intra-vascular immunostaining of fibrin on endothelial cells (arrow ×400). (E) Extra-vascular stromal staining (thin arrows) of fibrin near tumour cells (thick arrow ×400).
Affiliation: Angiogenesis Group, Oncology Center, St.-Augustinus Hospital, Oosterveldlaan 24, 2610 Wilrijk, Belgium.