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Arterio-venous gradients of IL-6, plasma and serum VEGF and D-dimers in human cancer.

Salgado R, Benoy I, Weytjens R, Van Bockstaele D, Van Marck E, Huget P, Hoylaerts M, Vermeulen P, Dirix LY - Br. J. Cancer (2002)

Bottom Line: In the megakaryoblastic cell line MEG-01, the expression of vascular endothelial growth factor-A was found to be regulated by interleukin-6.Our results suggest a pivotal role for interleukin-6 in the intrinsic link between haemostasis and angiogenesis.This might be of importance in the development of anti-angiogenic agents based on interference with haemostasis.

View Article: PubMed Central - PubMed

Affiliation: Angiogenesis Group, Oncology Center, St.-Augustinus Hospital, Oosterveldlaan 24, 2610 Wilrijk, Belgium.

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(A) VEGF-immunoreactivity in colorectal tumour cells (arrows ×400). (B) Interleukin-6-immunoreactivity in colorectal tumour cells (arrow ×400). (C) Adherence, aggregation and extravasation of platelets (thin arrows) in the vicinity of colorectal tumour cells (thick arrows ×400). (D) Intra-vascular immunostaining of fibrin on endothelial cells (arrow ×400). (E) Extra-vascular stromal staining (thin arrows) of fibrin near tumour cells (thick arrow ×400).
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fig1: (A) VEGF-immunoreactivity in colorectal tumour cells (arrows ×400). (B) Interleukin-6-immunoreactivity in colorectal tumour cells (arrow ×400). (C) Adherence, aggregation and extravasation of platelets (thin arrows) in the vicinity of colorectal tumour cells (thick arrows ×400). (D) Intra-vascular immunostaining of fibrin on endothelial cells (arrow ×400). (E) Extra-vascular stromal staining (thin arrows) of fibrin near tumour cells (thick arrow ×400).

Mentions: Seventy-five per cent of all patients involved with colorectal cancer (n=14) had tumour cell expression of VEGF-A (Figure 1AFigure 1


Arterio-venous gradients of IL-6, plasma and serum VEGF and D-dimers in human cancer.

Salgado R, Benoy I, Weytjens R, Van Bockstaele D, Van Marck E, Huget P, Hoylaerts M, Vermeulen P, Dirix LY - Br. J. Cancer (2002)

(A) VEGF-immunoreactivity in colorectal tumour cells (arrows ×400). (B) Interleukin-6-immunoreactivity in colorectal tumour cells (arrow ×400). (C) Adherence, aggregation and extravasation of platelets (thin arrows) in the vicinity of colorectal tumour cells (thick arrows ×400). (D) Intra-vascular immunostaining of fibrin on endothelial cells (arrow ×400). (E) Extra-vascular stromal staining (thin arrows) of fibrin near tumour cells (thick arrow ×400).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2376277&req=5

fig1: (A) VEGF-immunoreactivity in colorectal tumour cells (arrows ×400). (B) Interleukin-6-immunoreactivity in colorectal tumour cells (arrow ×400). (C) Adherence, aggregation and extravasation of platelets (thin arrows) in the vicinity of colorectal tumour cells (thick arrows ×400). (D) Intra-vascular immunostaining of fibrin on endothelial cells (arrow ×400). (E) Extra-vascular stromal staining (thin arrows) of fibrin near tumour cells (thick arrow ×400).
Mentions: Seventy-five per cent of all patients involved with colorectal cancer (n=14) had tumour cell expression of VEGF-A (Figure 1AFigure 1

Bottom Line: In the megakaryoblastic cell line MEG-01, the expression of vascular endothelial growth factor-A was found to be regulated by interleukin-6.Our results suggest a pivotal role for interleukin-6 in the intrinsic link between haemostasis and angiogenesis.This might be of importance in the development of anti-angiogenic agents based on interference with haemostasis.

View Article: PubMed Central - PubMed

Affiliation: Angiogenesis Group, Oncology Center, St.-Augustinus Hospital, Oosterveldlaan 24, 2610 Wilrijk, Belgium.

Show MeSH
Related in: MedlinePlus