Nuclear BAG-1 expression reflects malignant potential in colorectal carcinomas.
Bottom Line: The percentage of cases exhibiting nuclear BAG-1 positivity was significantly higher in distant metastasis-positive cases (55.6%) than in distant metastasis-negative cases (20.8%; P=0.036).Overall survival was significantly shorter for patients with tumours exhibiting BAG-1 positive nuclei than those with absent nuclear BAG-1-staining (P=0.011).In addition, the multivariate cox proportional hazard models indicated that nuclear BAG-1 expression was the only independent prognostic variable for mortality (P=0.013).
Affiliation: Department of Surgery II, Oita Medical University, 1-1 Idaigaoka, Hasama-machi, Oita 879-5593, Japan. email@example.comShow MeSH
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Mentions: There was significant variation in the immunohistochemical staining patterns of BAG-1 with tumours exhibiting absent staining and staining of either the cytoplasm, nucleus or both. The distinction between cytoplasmic and nuclear BAG-1 staining is demonstrated in Figure 1A,BFigure 1
Affiliation: Department of Surgery II, Oita Medical University, 1-1 Idaigaoka, Hasama-machi, Oita 879-5593, Japan. firstname.lastname@example.org