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Nuclear BAG-1 expression reflects malignant potential in colorectal carcinomas.

Kikuchi R, Noguchi T, Takeno S, Funada Y, Moriyama H, Uchida Y - Br. J. Cancer (2002)

Bottom Line: The percentage of cases exhibiting nuclear BAG-1 positivity was significantly higher in distant metastasis-positive cases (55.6%) than in distant metastasis-negative cases (20.8%; P=0.036).Overall survival was significantly shorter for patients with tumours exhibiting BAG-1 positive nuclei than those with absent nuclear BAG-1-staining (P=0.011).In addition, the multivariate cox proportional hazard models indicated that nuclear BAG-1 expression was the only independent prognostic variable for mortality (P=0.013).

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery II, Oita Medical University, 1-1 Idaigaoka, Hasama-machi, Oita 879-5593, Japan. kikuchir@oita-med.ac.jp

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Immunolocalisation of BAG-1 in samples of human colorectal carcinomas. Immunostaining revealed BAG-1 is immunostained in the tumour cell nucleus (A) and the cytoplasm (B: Original magnification ×400).
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fig1: Immunolocalisation of BAG-1 in samples of human colorectal carcinomas. Immunostaining revealed BAG-1 is immunostained in the tumour cell nucleus (A) and the cytoplasm (B: Original magnification ×400).

Mentions: There was significant variation in the immunohistochemical staining patterns of BAG-1 with tumours exhibiting absent staining and staining of either the cytoplasm, nucleus or both. The distinction between cytoplasmic and nuclear BAG-1 staining is demonstrated in Figure 1A,BFigure 1


Nuclear BAG-1 expression reflects malignant potential in colorectal carcinomas.

Kikuchi R, Noguchi T, Takeno S, Funada Y, Moriyama H, Uchida Y - Br. J. Cancer (2002)

Immunolocalisation of BAG-1 in samples of human colorectal carcinomas. Immunostaining revealed BAG-1 is immunostained in the tumour cell nucleus (A) and the cytoplasm (B: Original magnification ×400).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2376197&req=5

fig1: Immunolocalisation of BAG-1 in samples of human colorectal carcinomas. Immunostaining revealed BAG-1 is immunostained in the tumour cell nucleus (A) and the cytoplasm (B: Original magnification ×400).
Mentions: There was significant variation in the immunohistochemical staining patterns of BAG-1 with tumours exhibiting absent staining and staining of either the cytoplasm, nucleus or both. The distinction between cytoplasmic and nuclear BAG-1 staining is demonstrated in Figure 1A,BFigure 1

Bottom Line: The percentage of cases exhibiting nuclear BAG-1 positivity was significantly higher in distant metastasis-positive cases (55.6%) than in distant metastasis-negative cases (20.8%; P=0.036).Overall survival was significantly shorter for patients with tumours exhibiting BAG-1 positive nuclei than those with absent nuclear BAG-1-staining (P=0.011).In addition, the multivariate cox proportional hazard models indicated that nuclear BAG-1 expression was the only independent prognostic variable for mortality (P=0.013).

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery II, Oita Medical University, 1-1 Idaigaoka, Hasama-machi, Oita 879-5593, Japan. kikuchir@oita-med.ac.jp

Show MeSH
Related in: MedlinePlus