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Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects.

Dredge K, Marriott JB, Macdonald CD, Man HW, Chen R, Muller GW, Stirling D, Dalgleish AG - Br. J. Cancer (2002)

Bottom Line: The anti-tumour effects of thalidomide have been associated with its anti-angiogenic properties.Our results show that both the IMiDs and SelCIDs tested are significantly more potent than thalidomide.Identification of the differential effects of these compounds will enable targeting of such compounds into the appropriate clinical setting.

View Article: PubMed Central - PubMed

Affiliation: Division of Oncology, St. George's Hospital Medical School, Tooting, London SW17 0RE, UK. kdredge@sghms.ac.uk

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The effect of Thd, IMiDs and SelCIDs on bFGF and VEGF-induced HUVEC proliferative responses. The data is representative of three independent experiments.
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fig4: The effect of Thd, IMiDs and SelCIDs on bFGF and VEGF-induced HUVEC proliferative responses. The data is representative of three independent experiments.

Mentions: In the proliferation studies, we found that SelCID-2 and 3 inhibited bFGF and VEGF-induced proliferation (P<0.05) of HUVECs and EA.hy926 (data not shown for EA.hy926) but SelCID-1 had no effect of proliferative responses (Figure 4Figure 4


Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects.

Dredge K, Marriott JB, Macdonald CD, Man HW, Chen R, Muller GW, Stirling D, Dalgleish AG - Br. J. Cancer (2002)

The effect of Thd, IMiDs and SelCIDs on bFGF and VEGF-induced HUVEC proliferative responses. The data is representative of three independent experiments.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2376196&req=5

fig4: The effect of Thd, IMiDs and SelCIDs on bFGF and VEGF-induced HUVEC proliferative responses. The data is representative of three independent experiments.
Mentions: In the proliferation studies, we found that SelCID-2 and 3 inhibited bFGF and VEGF-induced proliferation (P<0.05) of HUVECs and EA.hy926 (data not shown for EA.hy926) but SelCID-1 had no effect of proliferative responses (Figure 4Figure 4

Bottom Line: The anti-tumour effects of thalidomide have been associated with its anti-angiogenic properties.Our results show that both the IMiDs and SelCIDs tested are significantly more potent than thalidomide.Identification of the differential effects of these compounds will enable targeting of such compounds into the appropriate clinical setting.

View Article: PubMed Central - PubMed

Affiliation: Division of Oncology, St. George's Hospital Medical School, Tooting, London SW17 0RE, UK. kdredge@sghms.ac.uk

Show MeSH
Related in: MedlinePlus