Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects.
Bottom Line: The anti-tumour effects of thalidomide have been associated with its anti-angiogenic properties.Our results show that both the IMiDs and SelCIDs tested are significantly more potent than thalidomide.Identification of the differential effects of these compounds will enable targeting of such compounds into the appropriate clinical setting.
Affiliation: Division of Oncology, St. George's Hospital Medical School, Tooting, London SW17 0RE, UK. email@example.comShow MeSH
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Mentions: In the proliferation studies, we found that SelCID-2 and 3 inhibited bFGF and VEGF-induced proliferation (P<0.05) of HUVECs and EA.hy926 (data not shown for EA.hy926) but SelCID-1 had no effect of proliferative responses (Figure 4Figure 4
Affiliation: Division of Oncology, St. George's Hospital Medical School, Tooting, London SW17 0RE, UK. firstname.lastname@example.org