Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects.
Bottom Line: The anti-tumour effects of thalidomide have been associated with its anti-angiogenic properties.Our results show that both the IMiDs and SelCIDs tested are significantly more potent than thalidomide.Identification of the differential effects of these compounds will enable targeting of such compounds into the appropriate clinical setting.
Affiliation: Division of Oncology, St. George's Hospital Medical School, Tooting, London SW17 0RE, UK. email@example.comShow MeSH
Related in: MedlinePlus
Mentions: Illustrates the effect of a thalidomide analogue, IMiD-1 (C,F) and suramin (B,E) in comparison to their relative controls (A,D) on microvessel outgrowths in the rat aorta assay (top row) and on tubule development in the human angiogenesis model (bottom row).
Affiliation: Division of Oncology, St. George's Hospital Medical School, Tooting, London SW17 0RE, UK. firstname.lastname@example.org