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Expression of cyclooxygenase-2 (COX-2) in tumour and stroma compartments in cervical cancer: clinical implications.

Ferrandina G, Lauriola L, Zannoni GF, Distefano MG, Legge F, Salutari V, Gessi M, Maggiano N, Scambia G, Ranelletti FO - Br. J. Cancer (2002)

Bottom Line: CD3, CD4, CD8, CD25, Mast Cell Tryptase monoclonal antibodies were used to characterise stroma inflammatory cells in nine cervical tumours.An inverse relation was found between cyclooxygenase-2 levels (cyclooxygenase-2 IDV) of tumour vs stroma compartment (r=-0.44, P<0.0001).The percentage of cases showing high tumour/stromal cyclooxygenase-2 IDV ratio was significantly higher in patients who did not respond to treatment (93.3%) with respect to patients with partial (60.5%), and complete (43.7%) response (P= 0.009).

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Largo F. Vito, I-00168 Rome, Italy.

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(A) Squamous cervical cancer with intense COX-2 immunoreaction in both cytoplasm and nuclei of tumour cells. Scattered cells in the stromal compartment are stained. (B) COX-2 negative tumour showing intense COX-2 staining in the stroma inflammatory compartment. CD3, CD4, CD25, and tryptase immunoreaction in tumours showing high (C, E, G) vs low (D, F, H) tumour/stroma COX-2 IDV ratio. Bar=50 μm (A,B); Bar=25 μm (C–H).
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fig1: (A) Squamous cervical cancer with intense COX-2 immunoreaction in both cytoplasm and nuclei of tumour cells. Scattered cells in the stromal compartment are stained. (B) COX-2 negative tumour showing intense COX-2 staining in the stroma inflammatory compartment. CD3, CD4, CD25, and tryptase immunoreaction in tumours showing high (C, E, G) vs low (D, F, H) tumour/stroma COX-2 IDV ratio. Bar=50 μm (A,B); Bar=25 μm (C–H).

Mentions: Figure 1AFigure 1


Expression of cyclooxygenase-2 (COX-2) in tumour and stroma compartments in cervical cancer: clinical implications.

Ferrandina G, Lauriola L, Zannoni GF, Distefano MG, Legge F, Salutari V, Gessi M, Maggiano N, Scambia G, Ranelletti FO - Br. J. Cancer (2002)

(A) Squamous cervical cancer with intense COX-2 immunoreaction in both cytoplasm and nuclei of tumour cells. Scattered cells in the stromal compartment are stained. (B) COX-2 negative tumour showing intense COX-2 staining in the stroma inflammatory compartment. CD3, CD4, CD25, and tryptase immunoreaction in tumours showing high (C, E, G) vs low (D, F, H) tumour/stroma COX-2 IDV ratio. Bar=50 μm (A,B); Bar=25 μm (C–H).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2376190&req=5

fig1: (A) Squamous cervical cancer with intense COX-2 immunoreaction in both cytoplasm and nuclei of tumour cells. Scattered cells in the stromal compartment are stained. (B) COX-2 negative tumour showing intense COX-2 staining in the stroma inflammatory compartment. CD3, CD4, CD25, and tryptase immunoreaction in tumours showing high (C, E, G) vs low (D, F, H) tumour/stroma COX-2 IDV ratio. Bar=50 μm (A,B); Bar=25 μm (C–H).
Mentions: Figure 1AFigure 1

Bottom Line: CD3, CD4, CD8, CD25, Mast Cell Tryptase monoclonal antibodies were used to characterise stroma inflammatory cells in nine cervical tumours.An inverse relation was found between cyclooxygenase-2 levels (cyclooxygenase-2 IDV) of tumour vs stroma compartment (r=-0.44, P<0.0001).The percentage of cases showing high tumour/stromal cyclooxygenase-2 IDV ratio was significantly higher in patients who did not respond to treatment (93.3%) with respect to patients with partial (60.5%), and complete (43.7%) response (P= 0.009).

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Largo F. Vito, I-00168 Rome, Italy.

Show MeSH
Related in: MedlinePlus