Elevated c-Src is linked to altered cell-matrix adhesion rather than proliferation in KM12C human colorectal cancer cells.
Bottom Line: Elevated expression and/or activity of c-Src, the prototype of the Src family of protein tyrosine kinases, is associated with the development of human colon cancer.Although elevated Src correlates with ability to metastasise to the liver after intrasplenic injection, we found that this was not linked to enhanced growth, either in vitro or in vivo as sub-cutaneous tumours.However, elevated Src was associated with enhanced attachment to extracellular matrix.
Affiliation: Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, Scotland, UK.Show MeSH
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Mentions: As well as growth responses in fibroblasts (reviewed in Abram and Courtneidge, 2000), SFKs also influence cell adhesion in both fibroblasts (Fincham and Frame, 1998) and osteoclasts (Schwartzberg et al, 1997). We found that cultures of KM12L4A metastatic cells contained substantially more vinculin-containing peripheral adhesion structures than their KM12C non-metastatic counterparts under normal growth conditions (Figure 3AFigure 3
Affiliation: Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, Scotland, UK.