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BAG-1 expression and function in human cancer.

Cutress RI, Townsend PA, Brimmell M, Bateman AC, Hague A, Packham G - Br. J. Cancer (2002)

Bottom Line: Interaction with chaperone molecules may mediate many of the effects of BAG-1.However, other studies of BAG-1 expression in breast cancer and other cancer types have yielded differing results.It is important to view these findings in the context of current knowledge of BAG-1 expression and function.

View Article: PubMed Central - PubMed

Affiliation: Cancer Research UK Oncology Unit, Cancer Sciences Division, Mail Point 824, School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. R.Cutress@soton.ac.uk

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Related in: MedlinePlus

BAG-1 binding partners and functions. BAG-1 interaction partners are indicated. Some of these interactions are direct, whereas others are probably mediated via binding to chaperone molecules, e.g., NHR. Interactions of BAG-1 with chaperones, E3 ligases and the proteasome suggest a key role in regulating the ubiquitin/proteasomal degradation system. Biological activities ascribed to BAG-1 are indicated below along with some potential molecular targets that might contribute to these effects. However, it is important to note that definitive evidence linking specific BAG-1 target molecules to biological responses is often lacking.
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fig2: BAG-1 binding partners and functions. BAG-1 interaction partners are indicated. Some of these interactions are direct, whereas others are probably mediated via binding to chaperone molecules, e.g., NHR. Interactions of BAG-1 with chaperones, E3 ligases and the proteasome suggest a key role in regulating the ubiquitin/proteasomal degradation system. Biological activities ascribed to BAG-1 are indicated below along with some potential molecular targets that might contribute to these effects. However, it is important to note that definitive evidence linking specific BAG-1 target molecules to biological responses is often lacking.

Mentions: In addition to these direct binding partners, several other proteins have been reported to interact with BAG-1 (Figure 2Figure 2


BAG-1 expression and function in human cancer.

Cutress RI, Townsend PA, Brimmell M, Bateman AC, Hague A, Packham G - Br. J. Cancer (2002)

BAG-1 binding partners and functions. BAG-1 interaction partners are indicated. Some of these interactions are direct, whereas others are probably mediated via binding to chaperone molecules, e.g., NHR. Interactions of BAG-1 with chaperones, E3 ligases and the proteasome suggest a key role in regulating the ubiquitin/proteasomal degradation system. Biological activities ascribed to BAG-1 are indicated below along with some potential molecular targets that might contribute to these effects. However, it is important to note that definitive evidence linking specific BAG-1 target molecules to biological responses is often lacking.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2376178&req=5

fig2: BAG-1 binding partners and functions. BAG-1 interaction partners are indicated. Some of these interactions are direct, whereas others are probably mediated via binding to chaperone molecules, e.g., NHR. Interactions of BAG-1 with chaperones, E3 ligases and the proteasome suggest a key role in regulating the ubiquitin/proteasomal degradation system. Biological activities ascribed to BAG-1 are indicated below along with some potential molecular targets that might contribute to these effects. However, it is important to note that definitive evidence linking specific BAG-1 target molecules to biological responses is often lacking.
Mentions: In addition to these direct binding partners, several other proteins have been reported to interact with BAG-1 (Figure 2Figure 2

Bottom Line: Interaction with chaperone molecules may mediate many of the effects of BAG-1.However, other studies of BAG-1 expression in breast cancer and other cancer types have yielded differing results.It is important to view these findings in the context of current knowledge of BAG-1 expression and function.

View Article: PubMed Central - PubMed

Affiliation: Cancer Research UK Oncology Unit, Cancer Sciences Division, Mail Point 824, School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. R.Cutress@soton.ac.uk

Show MeSH
Related in: MedlinePlus