Treatment of disseminated ocular melanoma with sequential fotemustine, interferon alpha, and interleukin 2.
Bottom Line: The only effective treatments reported to date relied on hepatic arterial chemoembolisation or -perfusion.Although objective responses were more frequent within the cohort receiving intraarterial fotemustine (21.7 vs 8%), this difference did not translate into a significant benefit in overall survival, i.e., 369 and 349 days, respectively.Of note, this overall survival is much longer than that repeatedly reported for stage IV uveal melanoma not treated with fotemustine, suggesting a therapeutic activity of this cytostatic drug even after systemic administration.
Affiliation: Department of Dermatology, University of Würzburg, Germany. email@example.comShow MeSH
Related in: MedlinePlus
Affiliation: Department of Dermatology, University of Würzburg, Germany. firstname.lastname@example.org