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Semen cryopreservation, utilisation and reproductive outcome in men treated for Hodgkin's disease.

Blackhall FH, Atkinson AD, Maaya MB, Ryder WD, Horne G, Brison DR, Lieberman BA, Radford JA - Br. J. Cancer (2002)

Bottom Line: Semen from 115 men was cryopreserved and after a median follow-up time of 10.1 years, 33 men have utilised stored semen (actuarial rate 27%) and nine partners have become pregnant resulting in 11 live births and one termination for foetal malformation.Actuarial 10 year rates of destruction of semen before death or utilisation and death before utilisation are 19% and 13% respectively.The high non-utilisation rate is intriguing and warrants further investigation.

View Article: PubMed Central - PubMed

Affiliation: Cancer Research UK Department of Medical Oncology, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK.

ABSTRACT
Between 1978 and 1990, 122 men underwent semen analysis before starting sterilising chemotherapy for Hodgkin's disease. Eighty-one (66%) had semen quality within the normal range, 25 were oligospermic (<20 x 10(6) sperm per ml) and five were azoospermic (no sperm in the ejaculate). Semen from 115 men was cryopreserved and after a median follow-up time of 10.1 years, 33 men have utilised stored semen (actuarial rate 27%) and nine partners have become pregnant resulting in 11 live births and one termination for foetal malformation. Actuarial 10 year rates of destruction of semen before death or utilisation and death before utilisation are 19% and 13% respectively. This retrospective cohort study demonstrates that approximately one-quarter of men utilising cryopreserved semen after treatment for Hodgkin's disease obtain a live birth. The high non-utilisation rate is intriguing and warrants further investigation.

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Related in: MedlinePlus

Cumulative rates of semen utilisation, death before utilisation and sample destruction without utilisation or death in patients with Hodgkin's disease (Kaplan–Meier method).
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fig3: Cumulative rates of semen utilisation, death before utilisation and sample destruction without utilisation or death in patients with Hodgkin's disease (Kaplan–Meier method).

Mentions: Data regarding utilisation was complete for 113 out of 115 patients who stored semen. The actuarial rate of utilisation 10 years from storage is 27%, the rate of destruction of semen without utilisation and before death of the patient is 19% and the rate of death without utilisation is 13% (Figure 3Figure 3


Semen cryopreservation, utilisation and reproductive outcome in men treated for Hodgkin's disease.

Blackhall FH, Atkinson AD, Maaya MB, Ryder WD, Horne G, Brison DR, Lieberman BA, Radford JA - Br. J. Cancer (2002)

Cumulative rates of semen utilisation, death before utilisation and sample destruction without utilisation or death in patients with Hodgkin's disease (Kaplan–Meier method).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2376135&req=5

fig3: Cumulative rates of semen utilisation, death before utilisation and sample destruction without utilisation or death in patients with Hodgkin's disease (Kaplan–Meier method).
Mentions: Data regarding utilisation was complete for 113 out of 115 patients who stored semen. The actuarial rate of utilisation 10 years from storage is 27%, the rate of destruction of semen without utilisation and before death of the patient is 19% and the rate of death without utilisation is 13% (Figure 3Figure 3

Bottom Line: Semen from 115 men was cryopreserved and after a median follow-up time of 10.1 years, 33 men have utilised stored semen (actuarial rate 27%) and nine partners have become pregnant resulting in 11 live births and one termination for foetal malformation.Actuarial 10 year rates of destruction of semen before death or utilisation and death before utilisation are 19% and 13% respectively.The high non-utilisation rate is intriguing and warrants further investigation.

View Article: PubMed Central - PubMed

Affiliation: Cancer Research UK Department of Medical Oncology, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK.

ABSTRACT
Between 1978 and 1990, 122 men underwent semen analysis before starting sterilising chemotherapy for Hodgkin's disease. Eighty-one (66%) had semen quality within the normal range, 25 were oligospermic (<20 x 10(6) sperm per ml) and five were azoospermic (no sperm in the ejaculate). Semen from 115 men was cryopreserved and after a median follow-up time of 10.1 years, 33 men have utilised stored semen (actuarial rate 27%) and nine partners have become pregnant resulting in 11 live births and one termination for foetal malformation. Actuarial 10 year rates of destruction of semen before death or utilisation and death before utilisation are 19% and 13% respectively. This retrospective cohort study demonstrates that approximately one-quarter of men utilising cryopreserved semen after treatment for Hodgkin's disease obtain a live birth. The high non-utilisation rate is intriguing and warrants further investigation.

Show MeSH
Related in: MedlinePlus