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Lack of mutations within ST7 gene in tumour-derived cell lines and primary epithelial tumours.

Brown VL, Proby CM, Barnes DM, Kelsell DP - Br. J. Cancer (2002)

Bottom Line: We have performed mutational analysis of ST7 in a wide-range of cell lines and primary epithelial cancers and detected only one missense change in a breast cancer cell line.Other mutations previously found in cell lines and primary tumours were not evident in our analysis.These results imply that another tumour suppressor gene at this locus may be more important than ST7 in carcinogenesis.

View Article: PubMed Central - PubMed

Affiliation: Centre for Cutaneous Research, Barts and The London, Queen Mary's School of Medicine and Dentistry, 2 Newark Street, Whitechapel, London E1 2AT, UK.

ABSTRACT
ST7 is a candidate tumour suppressor gene at human chromosome locus 7q31.1. We have performed mutational analysis of ST7 in a wide-range of cell lines and primary epithelial cancers and detected only one missense change in a breast cancer cell line. Other mutations previously found in cell lines and primary tumours were not evident in our analysis. These results imply that another tumour suppressor gene at this locus may be more important than ST7 in carcinogenesis.

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Related in: MedlinePlus

Sequence trace for MDA-MB435 breast cancer cell line (lower trace) showing a G→A substitution at codon 134 of ST7 compared to wild-type (upper trace).
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fig1: Sequence trace for MDA-MB435 breast cancer cell line (lower trace) showing a G→A substitution at codon 134 of ST7 compared to wild-type (upper trace).

Mentions: A single missense mutation in the breast cancer cell line MDA-MD435 was detected in exon 5 of ST7 (Figure 1Figure 1


Lack of mutations within ST7 gene in tumour-derived cell lines and primary epithelial tumours.

Brown VL, Proby CM, Barnes DM, Kelsell DP - Br. J. Cancer (2002)

Sequence trace for MDA-MB435 breast cancer cell line (lower trace) showing a G→A substitution at codon 134 of ST7 compared to wild-type (upper trace).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2376116&req=5

fig1: Sequence trace for MDA-MB435 breast cancer cell line (lower trace) showing a G→A substitution at codon 134 of ST7 compared to wild-type (upper trace).
Mentions: A single missense mutation in the breast cancer cell line MDA-MD435 was detected in exon 5 of ST7 (Figure 1Figure 1

Bottom Line: We have performed mutational analysis of ST7 in a wide-range of cell lines and primary epithelial cancers and detected only one missense change in a breast cancer cell line.Other mutations previously found in cell lines and primary tumours were not evident in our analysis.These results imply that another tumour suppressor gene at this locus may be more important than ST7 in carcinogenesis.

View Article: PubMed Central - PubMed

Affiliation: Centre for Cutaneous Research, Barts and The London, Queen Mary's School of Medicine and Dentistry, 2 Newark Street, Whitechapel, London E1 2AT, UK.

ABSTRACT
ST7 is a candidate tumour suppressor gene at human chromosome locus 7q31.1. We have performed mutational analysis of ST7 in a wide-range of cell lines and primary epithelial cancers and detected only one missense change in a breast cancer cell line. Other mutations previously found in cell lines and primary tumours were not evident in our analysis. These results imply that another tumour suppressor gene at this locus may be more important than ST7 in carcinogenesis.

Show MeSH
Related in: MedlinePlus