Increased expression of beta 2-microglobulin in multidrug-resistant tumour cells.
Bottom Line: The LMR-12/ beta2-m staining results were confirmed by mRNA microarray data from an independent National Cancer Institute study, as well as by newly obtained reverse transcriptase polymerase chain reaction data.Further analysis of the microarray data showed that beta2-m levels closely reflected levels of major histocompatibility complex class I heavy chains and the transporter associated with antigen processing.Since the ABC transporter associated with antigen processing was previously shown to contribute to multidrug-resistance, it may very well be that the observed LMR-12/ beta2-m levels are secondary to (elevated) levels of the transporter associated with antigen processing.
Affiliation: Department of Pathology, Free University Medical Center, Amsterdam, The Netherlands. email@example.comShow MeSH
Related in: MedlinePlus
Mentions: In a panel of 34 human tumours of different histogenetic origin, clear LMR-12/ β2-m staining was observed in ∼90% of the tumour samples, while the surrounding normal tissue always stained positive. The staining pattern of LMR-12/ β2-m was closely paralleled by W6/32 staining (Figure 4Figure 4
Affiliation: Department of Pathology, Free University Medical Center, Amsterdam, The Netherlands. firstname.lastname@example.org