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Cytokeratin 7 and 20 staining for the diagnosis of lung and colorectal adenocarcinoma.

Kummar S, Fogarasi M, Canova A, Mota A, Ciesielski T - Br. J. Cancer (2002)

Bottom Line: Tissue sections were stained for cytokeratin 7 and 20 and read as positive or negative for staining.The cytokeratin 7+/cytokeratin 20- pattern characterised 96% (29 out of 30) of primary and 95% (21 out of 22) of metastatic lung adenocarcinomas.Cytokeratin staining is helpful in the diagnostic differentiation of metastatic lesions from these two common primaries, and assists in determining the site of origin of metastatic lesions.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Yale Cancer Center, Yale University School of Medicine and VA Connecticut Cancer Center, VA Connecticut Healthcare System, 950 Campbell Avenue, 111D, West Haven, Connecticut, CT 06516, USA. kummars@yahoo.com

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CK20 (A) and CK7 (B) immunostaining of primary lung adenocarcinoma. CK20 (C) and CK7 (D) immunostain of metastatic lung adenocarcinoma to the liver. Most of the tumour cells in both the primary and the metastatic lesion show strong cytoplasmic staining with CK7 and negative staining with CK20 (original magnification 200×).
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fig1: CK20 (A) and CK7 (B) immunostaining of primary lung adenocarcinoma. CK20 (C) and CK7 (D) immunostain of metastatic lung adenocarcinoma to the liver. Most of the tumour cells in both the primary and the metastatic lesion show strong cytoplasmic staining with CK7 and negative staining with CK20 (original magnification 200×).

Mentions: In the initial phase of the study, the pattern of cytokeratin staining for primary lung and colorectal adenocarcinoma was evaluated. A total of 30 primary lung and 26 primary colorectal lesions were studied. All primary lung lesions were CK7+, and 29 of these were CK20− (Figure 1Figure 1


Cytokeratin 7 and 20 staining for the diagnosis of lung and colorectal adenocarcinoma.

Kummar S, Fogarasi M, Canova A, Mota A, Ciesielski T - Br. J. Cancer (2002)

CK20 (A) and CK7 (B) immunostaining of primary lung adenocarcinoma. CK20 (C) and CK7 (D) immunostain of metastatic lung adenocarcinoma to the liver. Most of the tumour cells in both the primary and the metastatic lesion show strong cytoplasmic staining with CK7 and negative staining with CK20 (original magnification 200×).
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Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2375436&req=5

fig1: CK20 (A) and CK7 (B) immunostaining of primary lung adenocarcinoma. CK20 (C) and CK7 (D) immunostain of metastatic lung adenocarcinoma to the liver. Most of the tumour cells in both the primary and the metastatic lesion show strong cytoplasmic staining with CK7 and negative staining with CK20 (original magnification 200×).
Mentions: In the initial phase of the study, the pattern of cytokeratin staining for primary lung and colorectal adenocarcinoma was evaluated. A total of 30 primary lung and 26 primary colorectal lesions were studied. All primary lung lesions were CK7+, and 29 of these were CK20− (Figure 1Figure 1

Bottom Line: Tissue sections were stained for cytokeratin 7 and 20 and read as positive or negative for staining.The cytokeratin 7+/cytokeratin 20- pattern characterised 96% (29 out of 30) of primary and 95% (21 out of 22) of metastatic lung adenocarcinomas.Cytokeratin staining is helpful in the diagnostic differentiation of metastatic lesions from these two common primaries, and assists in determining the site of origin of metastatic lesions.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Yale Cancer Center, Yale University School of Medicine and VA Connecticut Cancer Center, VA Connecticut Healthcare System, 950 Campbell Avenue, 111D, West Haven, Connecticut, CT 06516, USA. kummars@yahoo.com

Show MeSH
Related in: MedlinePlus