Limits...
The prognostic influence of bcl-2 in malignant glioma.

McDonald FE, Ironside JW, Gregor A, Wyatt B, Stewart M, Rye R, Adams J, Potts HW - Br. J. Cancer (2002)

Bottom Line: The bcl-2 gene is one of a complex group of genes which control programmed cell death.Bcl-2 immunostaining was assessed in 159 specimens from these patients, by scoring systems of 0 to 3 for intensity of scoring and proportion of cells staining.The expression of bcl-2 had a significant relationship with survival (univariate Cox model P=0.0302, hazard ratio 0.8, 95% confidence interval 0.65-0.98), with increased staining associated with improved survival.

View Article: PubMed Central - PubMed

Affiliation: Northern Centre for Cancer Treatment, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK. fionamcdonald@nuth.northy.nhs.uk

Show MeSH

Related in: MedlinePlus

Examples of Bcl-2 immunostaining scoring systems.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2375435&req=5

fig1: Examples of Bcl-2 immunostaining scoring systems.

Mentions: Immunostaining was assessed by semiquantitative scoring systems for percentage of cells staining and intensity of staining. Both were scored on scales of 0 to 3. For percentage of cells staining, a score of 0 represented no cells staining, a score of 1 represented less than 25%, a score of 2, 25 to 50%, and a score of 3 over 50% of cells staining. To establish a scale for intensity of staining an initial pilot group of sections was examined to observe the range of staining. A semiquantative scale of 0 to 3 was then used to assess the intensity of staining. See Figure 1Figure 1


The prognostic influence of bcl-2 in malignant glioma.

McDonald FE, Ironside JW, Gregor A, Wyatt B, Stewart M, Rye R, Adams J, Potts HW - Br. J. Cancer (2002)

Examples of Bcl-2 immunostaining scoring systems.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2375435&req=5

fig1: Examples of Bcl-2 immunostaining scoring systems.
Mentions: Immunostaining was assessed by semiquantitative scoring systems for percentage of cells staining and intensity of staining. Both were scored on scales of 0 to 3. For percentage of cells staining, a score of 0 represented no cells staining, a score of 1 represented less than 25%, a score of 2, 25 to 50%, and a score of 3 over 50% of cells staining. To establish a scale for intensity of staining an initial pilot group of sections was examined to observe the range of staining. A semiquantative scale of 0 to 3 was then used to assess the intensity of staining. See Figure 1Figure 1

Bottom Line: The bcl-2 gene is one of a complex group of genes which control programmed cell death.Bcl-2 immunostaining was assessed in 159 specimens from these patients, by scoring systems of 0 to 3 for intensity of scoring and proportion of cells staining.The expression of bcl-2 had a significant relationship with survival (univariate Cox model P=0.0302, hazard ratio 0.8, 95% confidence interval 0.65-0.98), with increased staining associated with improved survival.

View Article: PubMed Central - PubMed

Affiliation: Northern Centre for Cancer Treatment, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK. fionamcdonald@nuth.northy.nhs.uk

Show MeSH
Related in: MedlinePlus