Association of RET codon 691 polymorphism in radiation-induced human thyroid tumours with C-cell hyperplasia in peritumoural tissue.
Bottom Line: The RET proto-oncogene encodes a protein structurally related to transmembrane receptors with an intracellular tyrosine kinase domain.In human thyroid gland, the RET proto-oncogene is normally expressed in parafollicular C-cells.Several explanations for this association are discussed.
Affiliation: Laboratoire d'Instabilité Génétique et Cancer (UPR 2169), Institut de Recherches sur le Cancer, C.N.R.S.-IFR 89, B.P. no 8, 94801 Villejuif Cedex, France. BounacerA@cf.ac.ukShow MeSH
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Mentions: With the aim of determining a relationship between C-cell hyperplasia and the G691S RET SNP, we looked in the same thyroid sample for the polymorphism in the tumoural tissue and for the CCH in the surrounding peritumoural tissue. Our results showed that firstly, the majority of the radiation-induced tumours associated with a CCH (14/16: 88%), presented the polymorphism and interestingly, in 75% of the cases (12/16) only the mutated allele A2 was detected. Secondly, in the absence of CCH in peritumoural tissue only 14% (2/13) of the radiation-induced tumours presented a 691 RET sequence variant in heterozygote form (A1/A2) (Table 1 and Figure 2Figure 2
Affiliation: Laboratoire d'Instabilité Génétique et Cancer (UPR 2169), Institut de Recherches sur le Cancer, C.N.R.S.-IFR 89, B.P. no 8, 94801 Villejuif Cedex, France. BounacerA@cf.ac.uk