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Cell cycle phase perturbations and apoptosis in tumour cells induced by aplidine.

Erba E, Bassano L, Di Liberti G, Muradore I, Chiorino G, Ubezio P, Vignati S, Codegoni A, Desiderio MA, Faircloth G, Jimeno J, D'Incalci M - Br. J. Cancer (2002)

Bottom Line: The drug-induced cell cycle perturbations and subsequent cell death do not appear to be related to macromolecular synthesis (protein, RNA, DNA) since the effects occur at concentrations (e.g. 10 nM) in which macromolecule synthesis was not markedly affected.This finding has questionable relevance since addition of putrescine did not significantly reduce the cell cycle perturbations or the cytotoxicity of Aplidine.The cell cycle perturbations caused by Aplidine were also not due to an effect on the cyclin-dependent kinases.

View Article: PubMed Central - PubMed

Affiliation: Cancer Pharmacology Laboratory, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, 20157 Milan, Italy. erba@marionegri.it

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Related in: MedlinePlus

Aplidine chemical structure.
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fig1: Aplidine chemical structure.

Mentions: Aplidine, dehydrodidemnin B (Figure 1Figure 1


Cell cycle phase perturbations and apoptosis in tumour cells induced by aplidine.

Erba E, Bassano L, Di Liberti G, Muradore I, Chiorino G, Ubezio P, Vignati S, Codegoni A, Desiderio MA, Faircloth G, Jimeno J, D'Incalci M - Br. J. Cancer (2002)

Aplidine chemical structure.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2375382&req=5

fig1: Aplidine chemical structure.
Mentions: Aplidine, dehydrodidemnin B (Figure 1Figure 1

Bottom Line: The drug-induced cell cycle perturbations and subsequent cell death do not appear to be related to macromolecular synthesis (protein, RNA, DNA) since the effects occur at concentrations (e.g. 10 nM) in which macromolecule synthesis was not markedly affected.This finding has questionable relevance since addition of putrescine did not significantly reduce the cell cycle perturbations or the cytotoxicity of Aplidine.The cell cycle perturbations caused by Aplidine were also not due to an effect on the cyclin-dependent kinases.

View Article: PubMed Central - PubMed

Affiliation: Cancer Pharmacology Laboratory, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, 20157 Milan, Italy. erba@marionegri.it

Show MeSH
Related in: MedlinePlus