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The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer.

Turner KJ, Crew JP, Wykoff CC, Watson PH, Poulsom R, Pastorek J, Ratcliffe PJ, Cranston D, Harris AL - Br. J. Cancer (2002)

Bottom Line: Expression of both factors was greater in superficial disease.Unlike vascular endothelial growth factor, CA IX did not predict outcome in superficial disease.The expression of CA IX on the luminal surface justifies investigation of its utility as a therapeutic target/prognostic indicator.

View Article: PubMed Central - PubMed

Affiliation: ICRF Molecular Oncology Laboratory and Angiogenesis Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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Relationship of CA IX expression to microvessels in superficial (A) and invasive bladder cancer (B). Reduced from×40.
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fig3: Relationship of CA IX expression to microvessels in superficial (A) and invasive bladder cancer (B). Reduced from×40.

Mentions: In order to elucidate factors that might influence the expression of CA IX in bladder cancer, we examined the relationship between expression of CA IX and tumour microvessels. The distribution of CD 34 staining (as a marker of blood vessels) was compared to that of CA IX staining in the same sections for a subset of cases (52 vessels were assessed in 12 different cases, Figure 3Figure 3


The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer.

Turner KJ, Crew JP, Wykoff CC, Watson PH, Poulsom R, Pastorek J, Ratcliffe PJ, Cranston D, Harris AL - Br. J. Cancer (2002)

Relationship of CA IX expression to microvessels in superficial (A) and invasive bladder cancer (B). Reduced from×40.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2375338&req=5

fig3: Relationship of CA IX expression to microvessels in superficial (A) and invasive bladder cancer (B). Reduced from×40.
Mentions: In order to elucidate factors that might influence the expression of CA IX in bladder cancer, we examined the relationship between expression of CA IX and tumour microvessels. The distribution of CD 34 staining (as a marker of blood vessels) was compared to that of CA IX staining in the same sections for a subset of cases (52 vessels were assessed in 12 different cases, Figure 3Figure 3

Bottom Line: Expression of both factors was greater in superficial disease.Unlike vascular endothelial growth factor, CA IX did not predict outcome in superficial disease.The expression of CA IX on the luminal surface justifies investigation of its utility as a therapeutic target/prognostic indicator.

View Article: PubMed Central - PubMed

Affiliation: ICRF Molecular Oncology Laboratory and Angiogenesis Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK.

Show MeSH
Related in: MedlinePlus